Synaptic signalling in a network of dopamine neurons: what prevents proper intercellular crosstalk?
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13910
Abstract: Human embryonic stem cell (hESC)‐derived midbrain dopamine (DA) neurons stand out as a cell source for transplantation with their sustainability and consistency superior to the formerly used fetal tissues. However, multiple studies of DA neurons… read more here.
Keywords: synaptic signalling; signalling network; crosstalk; neurons prevents ... See more keywords
Molecular mechanism of the TP53-MDM2-AR-AKT signalling network regulation by USP12
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0283-3
Abstract: The TP53-MDM2-AR-AKT signalling network plays a critical role in the development and progression of prostate cancer. However, the molecular mechanisms regulating this signalling network are not completely defined. By conducting transcriptome analysis, denaturing immunoprecipitations and… read more here.
Keywords: cancer; tp53 mdm2; mdm2 akt; signalling network ... See more keywords
Insights into the molecular basis of c-di-GMP signalling in Pseudomonas aeruginosa.
Sign Up to like & getrecommendations! Published in 2022 at "Critical reviews in microbiology"
DOI: 10.1080/1040841x.2022.2154140
Abstract: The opportunistic human pathogen Pseudomonas aeruginosa can cause severe infections in immunocompromized people or cystic fibrosis (CF) patients. Because of its remarkable ability to invade the host and withstand the bacteriocidal effect of most conventional… read more here.
Keywords: pseudomonas aeruginosa; insights molecular; gmp; signalling network ... See more keywords
Application of Atlas of Cancer Signalling Network in preclinical studies
Sign Up to like & getrecommendations! Published in 2019 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bby031
Abstract: Cancer initiation and progression are associated with multiple molecular mechanisms. The knowledge of these mechanisms is expanding and should be converted into guidelines for tackling the disease. Here, we discuss the formalization of biological knowledge… read more here.
Keywords: network; cancer signalling; atlas cancer; omics data ... See more keywords