Rheumatoid arthritis: Modelling cytokine signalling networks
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Rheumatology"
DOI: 10.1038/nrrheum.2016.194
Abstract: Although an imbalance between proinflammatory and anti-inflammatory cytokines has been implicated in rheumatoid arthritis (RA), the identification of specific cytokines regulating RA pathophysiology is still challenging. Modelling cytokine signalling networks and evaluating associated pathway activities… read more here.
Keywords: cytokine signalling; modelling cytokine; arthritis modelling; rheumatoid arthritis ... See more keywords
Exploiting vulnerabilities in cancer signalling networks to combat targeted therapy resistance
Sign Up to like & getrecommendations! Published in 2018 at "Essays in Biochemistry"
DOI: 10.1042/ebc20180016
Abstract: Drug resistance remains one of the greatest challenges facing precision oncology today. Despite the vast array of resistance mechanisms that cancer cells employ to subvert the effects of targeted therapy, a deep understanding of cancer… read more here.
Keywords: cancer signalling; targeted therapy; resistance; cancer ... See more keywords
Reconstructing phosphorylation signalling networks from quantitative phosphoproteomic data
Sign Up to like & getrecommendations! Published in 2018 at "Essays in Biochemistry"
DOI: 10.1042/ebc20180019
Abstract: Cascades of phosphorylation between protein kinases comprise a core mechanism in the integration and propagation of intracellular signals. Although we have accumulated a wealth of knowledge around some such pathways, this is subject to study… read more here.
Keywords: reconstructing phosphorylation; quantitative phosphoproteomic; signalling networks; phosphoproteomic data ... See more keywords
Unravelling GPCR signalling networks using global phosphoproteomics.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of pharmacology"
DOI: 10.1111/bph.16052
Abstract: GPCR activation initiates signalling via a complex network of intracellular effectors that combine to produce diverse cellular and tissue responses. Although we have an advanced understanding of the proximal events following receptor stimulation, the molecular… read more here.
Keywords: unravelling gpcr; networks using; signalling networks; global phosphoproteomics ... See more keywords
MYC integrates FSH signalling networks in cumulus cells during bovine oocyte maturation.
Sign Up to like & getrecommendations! Published in 2022 at "Acta veterinaria Hungarica"
DOI: 10.1556/004.2022.00007
Abstract: Follicle-stimulating hormone (FSH) contributes to the acquisition of oocyte competence by modulating signalling pathways in cumulus cells (CCs), albeit much less is known about transcription factors (TFs) that orchestrate the downstream transcriptional changes. This work… read more here.
Keywords: integrates fsh; myc integrates; fsh signalling; signalling networks ... See more keywords