Effects of astaxanthin on sensory‐motor function in a compression model of spinal cord injury: Involvement of ERK and AKT signalling pathway
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pain"
DOI: 10.1002/ejp.1342
Abstract: Spinal cord injury (SCI) causes continuous neurological deficits and major sensory‐motor impairments. There is no effective treatment to enhance sensory‐motor function following SCI. Thus, it is crucial to develop novel therapeutics for this particular patient… read more here.
Keywords: motor function; sensory motor; signalling pathway; motor ... See more keywords
The Hippo in the room: Targeting the Hippo signalling pathway for osteosarcoma therapies
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29967
Abstract: Osteosarcoma (OS) is a primary malignant bone tumour which usually occurs in children and adolescents. OS is primarily a result of chromosomal aberrations, a combination of acquired genetic changes and, hereditary, resulting in the dysregulation… read more here.
Keywords: hippo signalling; hippo room; targeting hippo; room targeting ... See more keywords
Insulin Mediated Activation of PI3K/Akt Signalling Pathway Modifies the Proteomic Cargo of Extracellular Vesicles
Sign Up to like & getrecommendations! Published in 2017 at "PROTEOMICS"
DOI: 10.1002/pmic.201600371
Abstract: Epidemiological studies suggest that diabetes and obesity increases the risk of colorectal cancer (CRC) and lowers the patient survival rate. An important attribute in diabetes and obesity is the presence of high levels of growth… read more here.
Keywords: pi3k; pi3k akt; evs secreted; signalling pathway ... See more keywords
Proteomics coupled transcriptomics reveals lipopolysaccharide inhibiting peroxisome proliferator-activated receptors signalling pathway to reduce lipid droplets accumulation in mouse liver.
Sign Up to like & getrecommendations! Published in 2023 at "Proteomics"
DOI: 10.1002/pmic.202300043
Abstract: Lipid droplets (LDs) are multifunctional organelles consisting of a central compartment of non-polar lipids shielded from the cytoplasm by a phospholipid monolayer. The excessive accumulation of LDs in cells is closely related to the development… read more here.
Keywords: peroxisome proliferator; proliferator activated; lipid droplets; mouse liver ... See more keywords
Crucial role of Ca2+ /CN signalling pathway in the antifungal activity of Disenecioyl-cis-Khellactone against Botrytis cinerea.
Sign Up to like & getrecommendations! Published in 2022 at "Pest management science"
DOI: 10.1002/ps.7085
Abstract: BACKGROUND Botrytis cinerea causes grey mould and is one of the most destructive fungal pathogens affecting important fruit and vegetable crops. In preliminary studies, we found that Disenecioyl-cis-Khellactone(DK) had strong antifungal activity against several fungi… read more here.
Keywords: antifungal activity; ca2 signalling; signalling pathway; ca2 ... See more keywords
Indirect monitoring of TORC1 signalling pathway reveals molecular diversity among different yeast strains
Sign Up to like & getrecommendations! Published in 2019 at "Yeast"
DOI: 10.1002/yea.3351
Abstract: Saccharomyces cerevisiae is the main species responsible for the alcoholic fermentation in wine production. One of the main problems in this process is the deficiency of nitrogen sources in the grape must, which can lead… read more here.
Keywords: torc1; monitoring torc1; signalling pathway; pathway ... See more keywords
Toll-like receptor/interleukin-1 domain innate immune signalling pathway genetic variants are candidate predictors for severe gastrointestinal toxicity risk following 5-fluorouracil-based chemotherapy
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-018-3729-y
Abstract: PurposeSevere gastrointestinal (GI) toxicity is a common adverse effect following 5-fluorouracil (5-FU)-based chemotherapy treatment. The presence of severe GI toxicity leads to treatment revisions, sub-optimal therapy outcomes, and decreases to patients’ quality of life. There… read more here.
Keywords: risk; immune signalling; toxicity; signalling pathway ... See more keywords
Role of Notch in endothelial biology.
Sign Up to like & getrecommendations! Published in 2021 at "Angiogenesis"
DOI: 10.1007/s10456-021-09793-7
Abstract: The Notch signalling pathway is one of the main regulators of endothelial biology. In the last 20 years the critical function of Notch has been uncovered in the context of angiogenesis, participating in tip-stalk specification, arterial-venous… read more here.
Keywords: notch signalling; signalling pathway; role notch; biology ... See more keywords
Betaine promotes lipid accumulation in adipogenic-differentiated skeletal muscle cells through ERK/PPARγ signalling pathway
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-018-3299-7
Abstract: Betaine, a neutral zwitterionic compound, could regulate intramuscular fat (IMF) deposition and meat quality. However, the efficacy is controversial. Moreover, the regulatory mechanism of betaine on lipid metabolism in skeletal muscle cells remains unclear. Therefore,… read more here.
Keywords: skeletal muscle; accumulation; lipid accumulation; signalling pathway ... See more keywords
NLS-RARα blocks cell differentiation by inhibiting the retinoic acid signalling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.05.076
Abstract: A majority of acute promyelocytic leukaemia (APL) cases are characterized by the PML-RARα fusion gene. Previous studies have shown that neutrophil elastase (NE) can cleave PML-RARα and is important for the development of APL. Here,… read more here.
Keywords: rar; nls rar; cell differentiation; acid signalling ... See more keywords
Design, synthesis and structure-activity relationship optimization of phenanthridine derivatives as new Wnt/β-catenin signalling pathway agonists.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.11.020
Abstract: Phenanthridine derivativeHLY78 has previously been identified as the first Wnt/β-catenin signalling pathway agonist that targets the DAX domain of axin. However, due to the relatively weak activation on the Wnt/β-catenin signalling pathway, HLY78 is insufficient… read more here.
Keywords: catenin signalling; signalling pathway; structure activity; activity ... See more keywords