Human dendritic cells activated with MV130 induce Th1, Th17 and IL‐10 responses via RIPK2 and MyD88 signalling pathways
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201747024
Abstract: Recurrent respiratory tract infections (RRTIs) are the first leading cause of community‐ and nosocomial‐acquired infections. Antibiotics remain the mainstay of treatment, enhancing the potential to develop antibiotic resistances. Therefore, the development of new alternative approaches… read more here.
Keywords: signalling pathways; responses via; dendritic cells; th1 th17 ... See more keywords
Sphingosine‐1‐phosphate related signalling pathways manipulating virus replication
Sign Up to like & getrecommendations! Published in 2023 at "Reviews in Medical Virology"
DOI: 10.1002/rmv.2415
Abstract: Viruses can create a unique cellular environment that facilitates replication and transmission. Sphingosine kinases (SphKs) produce sphingosine‐1‐phosphate (S1P), a bioactive sphingolipid molecule that performs both physiological and pathological effects primarily by activating a subgroup of… read more here.
Keywords: replication; sphingosine; signalling pathways; virus ... See more keywords
Proteomic Approaches to Dissect Neuronal Signalling Pathways.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-15950-4_27
Abstract: With an increasing awareness of mental health issues and neurological disorders, "understanding the brain" is one of the biggest current challenges in biological research. This has been recognised by both governments and funding agencies, and… read more here.
Keywords: dissect neuronal; signalling pathways; neuronal signalling; proteomic approaches ... See more keywords
Probiotics Interactions and the Modulation of Major Signalling Pathways in Host Model Organism Caenorhabditis elegans.
Sign Up to like & getrecommendations! Published in 2021 at "Indian journal of microbiology"
DOI: 10.1007/s12088-021-00961-3
Abstract: Microorganisms live in the human digestive system and the gut microbiome constitutes part of our prime determining component for healthy aging and wellness. Gut microbiota has broad influences on its host, beginning from the digestion… read more here.
Keywords: organism; caenorhabditis elegans; model organism; signalling pathways ... See more keywords
Bu-Shen-Fang-Chuan formula attenuates cigarette smoke-induced inflammation by modulating the PI3K/Akt-Nrf2 and NF-κB signalling pathways.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.113095
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Chronic obstructive pulmonary disease (COPD) is a respiratory inflammatory disease. Unlike asthma, COPD is insensitive to glucocorticoid treatment; thus, it is of great importance to find alternative medications, including Chinese medicine, to suppress… read more here.
Keywords: signalling pathways; inflammation; pi3k akt; copd ... See more keywords
Beyond its antioxidant properties: Quercetin targets multiple signalling pathways in hepatocellular carcinoma in rats.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.116933
Abstract: AIMS Hepatocellular carcinoma (HCC) pathogenesis involves the interplay of multiple signalling pathways. Notch and Hedgehog (Hh) are two major developmental pathways that act in concert to regulate adult cell repair. CK2α -serine-threonine kinase-down-regulation enhanced apoptotic… read more here.
Keywords: hepatocellular carcinoma; carcinoma; multiple signalling; signalling pathways ... See more keywords
Wnt/B-catenin signalling facilitates cell fate decision making in the early mouse embryo
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2017.04.453
Abstract: to be faithfully maintained for normal homeostatic tissue functions. How cells integrate developmental and signalling-dependent instructions to acquire or alter transcriptional states remains a fundamental question in developmental biology. Polycomb and Trithorax group members act… read more here.
Keywords: signalling facilitates; chromatin; signalling pathways; catenin signalling ... See more keywords
Acquiring Control: The Evolution of Stomatal Signalling Pathways.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in plant science"
DOI: 10.1016/j.tplants.2019.01.002
Abstract: In vascular plants, stomata balance two opposing functions: they open to facilitate CO2 uptake and close to prevent excessive water loss. Here, we discuss the evolution of three major signalling pathways that are known to… read more here.
Keywords: evolution; control evolution; signalling pathways; evolution stomatal ... See more keywords
Notch and interacting signalling pathways in cardiac development, disease, and regeneration
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Cardiology"
DOI: 10.1038/s41569-018-0100-2
Abstract: Cardiogenesis is a complex developmental process involving multiple overlapping stages of cell fate specification, proliferation, differentiation, and morphogenesis. Precise spatiotemporal coordination between the different cardiogenic processes is ensured by intercellular signalling crosstalk and tissue–tissue interactions.… read more here.
Keywords: notch signalling; heart; signalling pathways; notch ... See more keywords
Epigenetics in renal cell cancer: mechanisms and clinical applications
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Urology"
DOI: 10.1038/s41585-018-0023-z
Abstract: Renal cell carcinoma (RCC) is characterized by an infrequent number of somatic mutations. By contrast, epigenetic aberrations are commonly found in RCC, indicating that epigenetic reprogramming is an important event in RCC development. Epigenetic alterations… read more here.
Keywords: renal cell; rcc; signalling pathways; cancer ... See more keywords
Signal profiling of the β1AR reveals coupling to novel signalling pathways and distinct phenotypic responses mediated by β1AR and β2AR
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-65636-3
Abstract: A comprehensive understanding of signalling downstream of GPCRs requires a broad approach to capture novel signalling modalities in addition to established pathways. Here, using an array of sixteen validated BRET-based biosensors, we analyzed the ability… read more here.
Keywords: signalling pathways; signal profiling; 1ar reveals; novel signalling ... See more keywords