ERK5 Signalling and Resistance to ERK1/2 Pathway Therapeutics: The Path Less Travelled?
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DOI: 10.3389/fcell.2022.839997
Abstract: The RAS-regulated RAF-MEK1/2-ERK1/2 signalling pathway is frequently de-regulated in human cancer. Melanoma in particular exhibits a high incidence of activating BRAFV600E/K and NRASQ61L/K mutations and such cells are addicted to the activity of these mutant… read more here.
Keywords: erk1 signalling; signalling resistance; erk5 signalling; erk1 ... See more keywords