Dact1 induces Dishevelled oligomerization to facilitate binding partner switch and signalosome formation during convergent extension
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-57658-0
Abstract: Convergent extension (CE) is a universal morphogenetic engine that promotes polarized tissue extension. In vertebrates, CE is regulated by non-canonical Wnt ligands signaling through “core” proteins of the planar cell polarity (PCP) pathway, including the… read more here.
Keywords: signalosome; oligomerization; extension; dact1 ... See more keywords
Ku70 senses cytosolic DNA and assembles a tumor-suppressive signalosome
Sign Up to like & getrecommendations! Published in 2024 at "Science Advances"
DOI: 10.1126/sciadv.adh3409
Abstract: The innate immune response contributes to the development or attenuation of acute and chronic diseases, including cancer. Microbial DNA and mislocalized DNA from damaged host cells can activate different host responses that shape disease outcomes.… read more here.
Keywords: signalosome; cytosolic dna; senses cytosolic; ku70 senses ... See more keywords
1570-P: COP9 Signalosome Is Required for Adipose Tissue Maintenance and Metabolic Health
Sign Up to like & getrecommendations! Published in 2025 at "Diabetes"
DOI: 10.2337/db25-1570-p
Abstract: Introduction and Objective: The COP9 (constitutive photomorphogenesis mutant 9) signalosome (CSN) is a regulatory particle of the ubiquitin (Ub) proteasome system (UPS) consisting of eight subunits (CSN1-CSN8). It is an essential regulator of cullin-RING-ubiquitin (Ub)… read more here.
Keywords: adipocyte; signalosome; metabolic health; adipose tissue ... See more keywords