EGFR ligands synergistically increase IL‐17A‐induced expression of psoriasis signature genes in human keratinocytes via IκBζ and Bcl3
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149706
Abstract: Various epidermal growth factor receptor (EGFR) ligands are highly expressed in the epidermis of psoriasis lesions, and abnormal EGFR activation appears to be involved in the pathogenesis of psoriasis. However, how EGFR signaling contributes to… read more here.
Keywords: egfr ligands; signature genes; psoriasis signature; expression ... See more keywords
Identification and validation of diagnostic signature genes in non-obstructive azoospermia by machine learning.
Sign Up to like & getrecommendations! Published in 2023 at "Aging"
DOI: 10.18632/aging.204749
Abstract: Non-obstructive azoospermia (NOA) is a common cause of male infertility, and no specific diagnostic indicators exist. In this study, we used human testis datasets GSE45885, GSE45887, and GSE108886 from GEO database as training datasets, and… read more here.
Keywords: non obstructive; validation; signature genes; machine learning ... See more keywords
Comprehensive epigenetic analysis of the signature genes in lung adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2017 at "Epigenomics"
DOI: 10.2217/epi-2017-0023
Abstract: AIM This study aimed to explore the epigenetic modifications of signature genes in lung adenocarcinoma. MATERIALS & METHODS The data of miRNA expression, mRNA expression and DNA methylation were downloaded from The Cancer Genome Atlas.… read more here.
Keywords: lung adenocarcinoma; analysis; signature genes; genes lung ... See more keywords
Protective effect of tertiary lymphoid structures against hepatocellular carcinoma: New findings from a genetic perspective
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1007426
Abstract: Background Tertiary lymphoid structures (TLS) have an effect on hepatocellular carcinoma (HCC), but the underlying mechanism remains to be elucidated. Methods Intratumoral TLS (iTLS) was classified in the Cancer Genome Atlas-Liver Hepatocellular Carcinoma (TCGA-LIHC) cohort… read more here.
Keywords: gene; hepatocellular carcinoma; effect; signature genes ... See more keywords
Analysis of signature genes and association with immune cells infiltration in pediatric septic shock
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1056750
Abstract: Background Early diagnosis of septic shock in children is critical for prognosis. This study committed to investigate the signature genes and their connection with immune cells in pediatric septic shock. Methods We screened a dataset… read more here.
Keywords: signature genes; signature; septic shock; analysis ... See more keywords
Monocytic Subsets Impact Cerebral Cortex and Cognition: Differences Between Healthy Subjects and Patients With First-Episode Schizophrenia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.900284
Abstract: Monocytes are a highly heterogeneous population subcategorized into classical, intermediate and nonclassical subsets. How monocytes and their subsets may shape brain structures and functions in schizophrenia remains unclear. The primary goal of this cross-sectional study… read more here.
Keywords: cognition; episode schizophrenia; first episode; signature genes ... See more keywords
Identification of cuproptosis-associated subtypes and signature genes for diagnosis and risk prediction of Ulcerative colitis based on machine learning
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1142215
Abstract: Background Ulcerative colitis (UC) is a chronic and debilitating inflammatory bowel disease that impairs quality of life. Cuproptosis, a recently discovered form of cell death, has been linked to many inflammatory diseases, including UC. This… read more here.
Keywords: signature genes; cuproptosis; analysis; machine learning ... See more keywords
Comparative Transcriptomic and Lipidomic Analyses of Human Male and Female Meibomian Glands Reveal Common Signature Genes of Meibogenesis
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20184539
Abstract: Meibum is a lipid secretion that is produced by holocrine Meibomian glands (MGs). MGs are a specialized type of sebaceous glands that are embedded in the human eyelids. Chemically, meibum and sebum are different. A… read more here.
Keywords: meibum; meibomian glands; signature genes; genes meibogenesis ... See more keywords
Recognition of a Novel Gene Signature for Human Glioblastoma
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23084157
Abstract: Glioblastoma (GBM) is one of the most common malignant and incurable brain tumors. The identification of a gene signature for GBM may be helpful for its diagnosis, treatment, prediction of prognosis and even the development… read more here.
Keywords: glioblastoma; signature; signature genes; gene signature ... See more keywords
Comparative Analyses of Signature Genes in Acute Rejection and Operational Tolerance
Sign Up to like & getrecommendations! Published in 2017 at "Immune Network"
DOI: 10.4110/in.2017.17.4.237
Abstract: Using biomarkers as prediction tools or therapeutic targets can be a valuable strategy in transplantation. Recent studies identified biomarkers of acute rejection (AR) and operational tolerance (TOL) through the application of meta-analysis. In this study,… read more here.
Keywords: analysis; acute rejection; signature genes; operational tolerance ... See more keywords