Mutational Signatures in Cancer (MuSiCa): a web application to implement mutational signatures analysis in cancer samples
Sign Up to like & getrecommendations! Published in 2018 at "BMC Bioinformatics"
DOI: 10.1186/s12859-018-2234-y
Abstract: BackgroundMutational signatures have been proved as a valuable pattern in somatic genomics, mainly regarding cancer, with a potential application as a biomarker in clinical practice. Up to now, several bioinformatic packages to address this topic… read more here.
Keywords: cancer samples; cancer musica; application; signatures cancer ... See more keywords
Epigenetic signatures in cancer: proper controls, current challenges and the potential for clinical translation
Sign Up to like & getrecommendations! Published in 2021 at "Genome Medicine"
DOI: 10.1186/s13073-021-00837-7
Abstract: Epigenetic alterations are associated with normal biological processes such as aging or differentiation. Changes in global epigenetic signatures, together with genetic alterations, are driving events in several diseases including cancer. Comparative studies of cancer and… read more here.
Keywords: epigenetic patterns; cancer epigenomes; epigenetic signatures; signatures cancer ... See more keywords
Analysis of inflammatory signatures of cancer spheroids in blood and their role in metastasis.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.3090
Abstract: 3090Background: Cancer mortality correlates with metastatic progression where genetic/epigenetic changes in the cancer are important. Recent data indicate, however, that the host thrombotic and inf... read more here.
Keywords: analysis inflammatory; spheroids blood; cancer spheroids; signatures cancer ... See more keywords
Integrated structural variation and point mutation signatures in cancer genomes using correlated topic models
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1006799
Abstract: Mutation signatures in cancer genomes reflect endogenous and exogenous mutational processes, offering insights into tumour etiology, features for prognostic and biologic stratification and vulnerabilities to be exploited therapeutically. We present a novel machine learning formalism… read more here.
Keywords: correlated topic; mutation signatures; signatures cancer; cancer ... See more keywords