Signatures of natural selection and ethnic-specific prevalence of NPC1 pathogenic mutations contributing to obesity and Niemann–Pick disease type C1
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DOI: 10.1038/s41598-020-75919-4
Abstract: While homozygous pathogenic mutations in the NPC1 gene cause Niemann-Pick type C1 disease, heterozygous mutations cause highly-penetrant obesity. We aimed to investigate the prevalence of NPC1 mutations and their signatures of natural selection in 122,678… read more here.
Keywords: pathogenic mutations; selection; obesity; signatures natural ... See more keywords
Signatures of natural selection in a foundation tree along Mediterranean climatic gradients
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DOI: 10.1111/mec.16351
Abstract: Temperature and precipitation regimes are rapidly changing, resulting in forest dieback and extinction events, particularly in Mediterranean‐type climates (MTC). Forest management that enhance forests’ resilience is urgently required, however adaptation to climates in heterogeneous landscapes… read more here.
Keywords: temperature precipitation; signatures natural; snps associated; selection ... See more keywords
Identifying signatures of natural selection in Indian populations
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DOI: 10.1371/journal.pone.0271767
Abstract: In this study, we present the results of a genome-wide scan for signatures of positive selection using data from four tribal groups (Kokana, Warli, Bhil, and Pawara) and two caste groups (Deshastha Brahmin and Kunbi… read more here.
Keywords: indian populations; identifying signatures; selection indian; natural selection ... See more keywords
Signatures of natural selection in morphological quantitative traits in Argentinean populations of Senegalia gilliesii (Fabaceae).
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DOI: 10.1590/0001-3765202120201673
Abstract: In order to elucidate the role of evolutionary forces in shaping the variation of quantitative traits in Senegalia gilliesii we evaluate seven phenotypic traits in three Argentinean populations, two of them sharing environmental and vegetation… read more here.
Keywords: argentinean populations; selection; phenotypic traits; senegalia gilliesii ... See more keywords