The Fragility of Statistically Significant Results in Randomized Clinical Trials for COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.2973
Abstract: Key Points Question In randomized clinical trials (RCTs) of COVID-19 that report statistically significant results, what is the fragility index, ie, the minimum number of participants who would need to have had a different outcome… read more here.
Keywords: clinical trials; significant results; fragility; randomized clinical ... See more keywords
A review of high impact journals found that misinterpretation of non-statistically significant results from randomised trials was common.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of clinical epidemiology"
DOI: 10.1016/j.jclinepi.2022.01.014
Abstract: OBJECTIVES To determine the prevalence of poor interpretation practices, such as conflating evidence of absence with absence of evidence and over-emphasis of statistical non-significance in abstract conclusions, in a sample of randomised controlled trials (RCTs)… read more here.
Keywords: high impact; non statistically; statistically significant; evidence ... See more keywords
The fragility of statistically significant results in gynecologic surgery: A systematic review.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC"
DOI: 10.1016/j.jogc.2021.11.016
Abstract: OBJECTIVE To use the fragility index (FI) to evaluate the robustness of gynaecologic surgery trials that report statistically significant results. The FI defines the minimum number of patients who must have an alternative outcome to… read more here.
Keywords: gynaecology; statistically significant; fragility; gynaecologic surgery ... See more keywords
Efficient derivation of significant results from mechanical processing experiments with mixed solid waste: Coarse-shredding of commercial waste.
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DOI: 10.1016/j.wasman.2020.12.015
Abstract: Deriving significant experiment-based conclusions on mechanical processing of mixed solid waste is challenging: the input material cannot be downscaled in a way that enables drawing transferable conclusions from lab-scale experiments. Hence experiments need to be… read more here.
Keywords: mechanical processing; mixed solid; waste; significant results ... See more keywords
Comment on "Long-term Outcome of Surgery Versus Conservative Management for Recurrent and Ongoing Complaints After an Episode of Diverticulitis": Statistically Significant Results Are Not Necessarily Clinically Important.
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Surgery"
DOI: 10.1097/sla.0000000000003809
Abstract: To the Editor: C linical trial results that are statistically significant are routinely considered to be clinically important, and conversely, those with statistically insignificant results are interpreted as being clinically unimportant. However, statistical and clinical… read more here.
Keywords: statistically significant; clinically important; significant results; sample size ... See more keywords