Discovery and Optimization of Potent PROTAC Degraders of Phosphoinositide 3-Kinase with Significant in Vivo Anticancer Efficacy.
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DOI: 10.1021/acs.jmedchem.5c00679
Abstract: The aberrant activation of the phosphoinositide 3-kinase (PI3K) pathway is closely linked to the progression of various cancers, highlighting its significance as a target for cancer therapy. In contrast to conventional PI3K inhibitors, the selective… read more here.
Keywords: anticancer efficacy; protac degraders; vivo anticancer; significant vivo ... See more keywords