Sildenafil, unbridled optimism, and heart failure with preserved ejection fraction
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.690
Abstract: Despite compelling evidence to the contrary, we in the cardiovascular community have maintained an unbridled sense of optimism that phosphodiesterase 5 inhibitors (PDE5i) such as sildenafil might still be effective to help our patients suffering… read more here.
Keywords: failure preserved; optimism; sildenafil; heart failure ... See more keywords
Is sildenafil neutral on cardiopulmonary performance in group 2 pulmonary hypertension? More details for interpretation
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.753
Abstract: I read with interest and attention the recently published paper by Liu and co-workers1 looking at the effects of sildenafil on cardiac function and cardiopulmonary exercise testing (CPET) response after 12 weeks of phosphodiesterase 5… read more here.
Keywords: pulmonary hypertension; group; sildenafil; exercise ... See more keywords
PDE5 inhibitor sildenafil attenuates cardiac microRNA 214 upregulation and pro-apoptotic signaling after chronic alcohol ingestion in mice
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-020-03779-7
Abstract: Abusive chronic alcohol consumption can cause metabolic and functional derangements in the heart and is a risk factor for development of non-ischemic cardiomyopathy. microRNA 214 (miR-214) is a molecular sensor of stress signals that negatively… read more here.
Keywords: pde5 inhibitor; microrna 214; sildenafil; mir 214 ... See more keywords
Direct comparison of tadalafil with sildenafil for the treatment of erectile dysfunction: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2017 at "International Urology and Nephrology"
DOI: 10.1007/s11255-017-1644-5
Abstract: AimsErectile dysfunction (ED) is a major care problem worldwide. Tadalafil and sildenafil are the two most common phosphodiesterase 5 inhibitors used to treat ED. This systematic review and meta-analysis were conducted to directly compare tadalafil… read more here.
Keywords: sildenafil; treatment; tadalafil sildenafil; meta analysis ... See more keywords
Pharmacokinetics of a Novel Sildenafil Orodispersible Film Administered by the Supralingual and the Sublingual Route to Healthy Men
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Drug Investigation"
DOI: 10.1007/s40261-018-0665-x
Abstract: BackgroundSildenafil was the first selective drug available on the market as oral therapy for erectile dysfunction (ED). A novel sildenafil orodispersible film (ODF) for ED treatment, containing sildenafil citrate, has recently been marketed.ObjectivesStudy objective was… read more here.
Keywords: administration; sildenafil orodispersible; supralingual administration; novel sildenafil ... See more keywords
A gold nanoparticle-based immunochromatographic assay for simultaneous detection of multiplex sildenafil adulterants in health food by only one antibody.
Sign Up to like & getrecommendations! Published in 2021 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2020.10.032
Abstract: In the last few years, sildenafil and its analogues have emerged as an illegal ingredient in health food and products, causing illness and death. To address this problem, herein, a gold nanoparticle-based immunochromatographic assay for… read more here.
Keywords: detection; nanoparticle based; sildenafil; gold nanoparticle ... See more keywords
The utility of CYP3A activity endogenous markers for evaluating drug-drug interaction between sildenafil and CYP3A inhibitors in healthy subjects.
Sign Up to like & getrecommendations! Published in 2020 at "Drug metabolism and pharmacokinetics"
DOI: 10.1016/j.dmpk.2020.11.003
Abstract: Cytochrome P450 (CYP) 3A-related drug-drug interaction (DDI) studies are needed during drug development to determine clinical interaction effects. We aimed to evaluate DDI between sildenafil and two CYP3A inhibitors, clarithromycin and itraconazole, regarding the changes… read more here.
Keywords: endogenous markers; cyp3a activity; drug; sildenafil ... See more keywords
Sildenafil protects against bile duct ligation induced hepatic fibrosis in rats: Potential role for silent information regulator 1 (SIRT1)
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2017.09.021
Abstract: ABSTRACT Hepatic fibrosis is a potential health problem that may end with life‐threatening cirrhosis and primary liver cancer. Recent studies point out to the protective effects of silent information regulator1 (SIRT1), against different models of… read more here.
Keywords: sirt1; fibrosis; sildenafil; hepatic fibrosis ... See more keywords
Association between oral sildenafil dosing, predicted exposure, and systemic hypotension in hospitalised infants
Sign Up to like & getrecommendations! Published in 2017 at "Cardiology in the Young"
DOI: 10.1017/s1047951117001639
Abstract: Abstract Background The relationship between sildenafil dosing, exposure, and systemic hypotension in infants is incompletely understood. Objectives The aim of this study was to characterise the relationship between predicted sildenafil exposure and hypotension in hospitalised… read more here.
Keywords: exposure systemic; exposure; sildenafil; systemic hypotension ... See more keywords
Intra-amniotic Sildenafil Treatment Modulates Vascular Smooth Muscle Cell Phenotype in the Nitrofen Model of Congenital Diaphragmatic Hernia
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-34948-w
Abstract: The etiology of pulmonary vascular abnormalities in CDH is incompletely understood. Studies have demonstrated improvement in pulmonary vasculature with prenatal therapy in animal models. We hypothesize that prenatal sildenafil may attenuate defective pulmonary vascular development… read more here.
Keywords: phenotype; vsmc phenotype; nitrofen model; sildenafil ... See more keywords
Thioredoxin-1 is required for the cardioprotecive effect of sildenafil against ischaemia/reperfusion injury and mitochondrial dysfunction in mice
Sign Up to like & getrecommendations! Published in 2019 at "Free Radical Research"
DOI: 10.1080/10715762.2019.1661404
Abstract: Abstract Sildenafil is a phosphodiesterase type 5 inhibitor which confers cardioprotection against myocardial ischaemia/reperfusion (I/R) injury. The aim of this study was to determine if Trx1 participates in cardioprotection exerted by sildenafil in an acute… read more here.
Keywords: trx1; reperfusion; effect; ischaemia ... See more keywords