Cyclic guanosine monophosphate modulates accumulation of phosphodiesterase 5 inhibitors in human platelets
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2017.08.026
Abstract: ABSTRACT Sildenafil and tadalafil are widely‐used phosphodiesterase 5 (PDE5) inhibitors for which no clear dose‐response relationship could be established. Using isolated and/or recombinant PDE5, it has been demonstrated that cGMP can increase the affinity of… read more here.
Keywords: guanosine monophosphate; sildenafil tadalafil; tadalafil; pde5 ... See more keywords
Survey on Sildenafil, Tadalafil, and Vardenafil Concentrations in Food Supplements for Erectile Dysfunction
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Analytical Chemistry"
DOI: 10.1155/2022/3950190
Abstract: The aim of the study was to analyze the presence of undeclared sildenafil, tadalafil, and vardenafil in food supplements (FSs) for erectile dysfunction. The presence of sildenafil, tadalafil, and vardenafil was determined using the generated… read more here.
Keywords: sildenafil tadalafil; food supplements; tadalafil vardenafil; erectile dysfunction ... See more keywords
Simultaneous LC-MS analysis of plasma concentrations of sildenafil, tadalafil, bosentan, ambrisentan, and macitentan in patients with pulmonary arterial hypertension.
Sign Up to like & getrecommendations! Published in 2020 at "Die Pharmazie"
DOI: 10.1691/ph.2020.0021
Abstract: Phosphodiesterase-5 (PDE-5) inhibitors and endothelin receptor antagonists (ERAs) are standard therapies for pulmonary arterial hypertension (PAH). The inter-individual variability of these pharmacokinetics is reported remarkably large, and therapeutic drug monitoring (TDM) can be useful to… read more here.
Keywords: plasma; arterial hypertension; sildenafil tadalafil; plasma concentrations ... See more keywords
Sildenafil Vs. Tadalafil for The Treatment of Benign Prostatic Hyperplasia: A Single-arm Self-controlled Clinical Trial.
Sign Up to like & getrecommendations! Published in 2023 at "Urology journal"
DOI: 10.22037/uj.v20i.7593
Abstract: PURPOSE To compare the efficacy and adverse events of sildenafil monotherapy for benign prostatic hyperplasia (BPH) with its FDA-approved counterpart, tadalafil. MATERIALS AND METHODS In this single-arm self-controlled clinical trial, 33 patients were enrolled. All… read more here.
Keywords: ipss; index; sildenafil tadalafil; tadalafil ... See more keywords