Sildenafil treatment of vascular dementia in aged rats
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DOI: 10.1016/j.neuint.2018.12.015
Abstract: BACKGROUND and purpose: In this study, we employed a multiple microinfarction (MMI) based vascular dementia (VaD) model in aged rats and tested the therapeutic effects of Sildenafil, a phosphodiesterase type 5 inhibitor, on cognitive decline,… read more here.
Keywords: aged rats; sildenafil treatment; mmi; vascular dementia ... See more keywords
Intra-amniotic Sildenafil Treatment Modulates Vascular Smooth Muscle Cell Phenotype in the Nitrofen Model of Congenital Diaphragmatic Hernia
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DOI: 10.1038/s41598-018-34948-w
Abstract: The etiology of pulmonary vascular abnormalities in CDH is incompletely understood. Studies have demonstrated improvement in pulmonary vasculature with prenatal therapy in animal models. We hypothesize that prenatal sildenafil may attenuate defective pulmonary vascular development… read more here.
Keywords: phenotype; vsmc phenotype; nitrofen model; sildenafil ... See more keywords
Abstract TMP120: Sildenafil Treatment of Vascular Dementia in Aged Rats
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DOI: 10.1161/str.50.suppl_1.tmp120
Abstract: Background and Purpose: Vascular Dementia (VaD) caused by silent or mini strokes, affects cognition and memory predominantly in the elderly. Sildenafil, a cGMP-specific phosphodiesterase type 5 inh... read more here.
Keywords: abstract tmp120; sildenafil treatment; dementia; tmp120 sildenafil ... See more keywords