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Sildenafil, a Type-5 Phosphodiesterase Inhibitor, Fails to Reverse Myeloid-Derived Suppressor Cell-Mediated T Cell Suppression in Cells Isolated From Tuberculosis Patients

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Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2022.883886

Abstract: Successful TB treatment is hampered by increasing resistance to the two most effective first-line anti-TB drugs, namely isoniazid and rifampicin, thus innovative therapies focused on host processes, termed host-directed therapies (HDTs), are promising novel approaches… read more here.

Keywords: type phosphodiesterase; cell; myeloid derived; sildenafil type ... See more keywords