Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex.
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DOI: 10.1039/d3cc01143g
Abstract: To ensure specificity of small interfering RNAs (siRNAs), the antisense strand must be selected by the RNA-induced silencing complex (RISC). We have previously demonstrated that a 5'-morpholino-modified nucleotide at the 5'-end of the sense strand… read more here.
Keywords: silencing complex; strand; induced silencing; rna induced ... See more keywords