Telomerase Reverse Transcriptase Deficiency Prevents Neointima Formation Through Chromatin Silencing of E2F1 Target Genes
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DOI: 10.1161/atvbaha.116.308717
Abstract: Objective— Aberrant proliferation of smooth muscle cells (SMC) in response to injury induces pathological vascular remodeling during atherosclerosis and neointima formation. Telomerase is rate limiting for tissue renewal and cell replication; however, the physiological role… read more here.
Keywords: silencing e2f1; telomerase reverse; formation; tert ... See more keywords