Abstract 5223: Epigenetic silencing mediated by non-phosphorylated STAT5B prevents differentiation in acute myeloid leukemia
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DOI: 10.1158/1538-7445.sabcs18-5223
Abstract: STAT5 proteins are transcription factors involved in the regulation of proliferation, apoptosis and differentiation. Upon ligand-mediated activation, phosphorylated STAT5A (pSTAT5A) and pSTAT5B form homo- or heterodimers, translocate to the nucleus and activate transcription. Recent data… read more here.
Keywords: differentiation; aml cells; stat5b; epigenetic silencing ... See more keywords