A somatic role for the histone methyltransferase Setdb1 in endogenous retrovirus silencing
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04132-9
Abstract: Subsets of endogenous retroviruses (ERVs) are derepressed in mouse embryonic stem cells (mESCs) deficient for Setdb1, which catalyzes histone H3 lysine 9 trimethylation (H3K9me3). Most of those ERVs, including IAPs, remain silent if Setdb1 is… read more here.
Keywords: setdb1; silencing somatic; erv silencing; somatic role ... See more keywords