Silent genetic alterations identified by targeted next-generation sequencing in pheochromocytoma/paraganglioma: A clinicopathological correlations.
Sign Up to like & getrecommendations! Published in 2017 at "Experimental and molecular pathology"
DOI: 10.1016/j.yexmp.2016.12.007
Abstract: AIMS The goal of this pilot study was to develop a customized, cost-effective amplicon panel (Ampliseq) for target sequencing in a cohort of patients with sporadic phaeochromocytoma/paraganglioma. METHODS Phaeochromocytoma/paragangliomas from 25 patients were analysed by… read more here.
Keywords: targeted next; ingenuity; silent genetic; next generation ... See more keywords
A mutational hotspot that determines highly repeatable evolution can be built and broken by silent genetic changes.
Sign Up to like & getrecommendations! Published in 2021 at "Nature communications"
DOI: 10.1038/s41467-021-26286-9
Abstract: Mutational hotspots can determine evolutionary outcomes and make evolution repeatable. Hotspots are products of multiple evolutionary forces including mutation rate heterogeneity, but this variable is often hard to identify. In this work, we reveal that… read more here.
Keywords: built broken; evolution; mutational hotspot; highly repeatable ... See more keywords