Modulatory effects of silibinin in cell behavior during osteogenic phenotype
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28616
Abstract: Natural molecules, such as flavonoid, are very welcome strategies to modulate bone turnover. This prompted us to comprehend better the effect of silibinin on osteoblast metabolism, mainly considering intracellular pathways able to drive cell adhesion… read more here.
Keywords: phenotype; effect silibinin; modulatory effects; silibinin ... See more keywords
Silibinin treatment results in reducing OPA1&MFN1 genes expression in a rat model hepatic ischemia–reperfusion
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology Reports"
DOI: 10.1007/s11033-020-05383-w
Abstract: The mitochondrial damage has a pivotal role in triggering apoptosis and cell death. This study assessed the effect of silibinin on optical atrophy-1 (OPA1) and mitofusin-1 (MFN1) gene expression in liver tissue during hepatic warm… read more here.
Keywords: tissue; reperfusion; silibinin treatment; ischemia ... See more keywords
Antioxidative and Anti-Apoptotic Roles of Silibinin in Reversing Learning and Memory Deficits in APP/PS1 Mice
Sign Up to like & getrecommendations! Published in 2017 at "Neurochemical Research"
DOI: 10.1007/s11064-017-2389-3
Abstract: Silibinin has been widely used to treat liver diseases due to its antioxidant activity. However, the effects of silibinin on the central nervous system have not been thoroughly investigated. The pathological hallmarks of Alzheimer’s disease… read more here.
Keywords: anti apoptotic; ps1 mice; antioxidative anti; silibinin ... See more keywords
Silibinin Alleviates the Learning and Memory Defects in Overtrained Rats Accompanying Reduced Neuronal Apoptosis and Senescence
Sign Up to like & getrecommendations! Published in 2019 at "Neurochemical Research"
DOI: 10.1007/s11064-019-02816-2
Abstract: Excessive physical exercise (overtraining; OT) increases oxidative stress and induces damage in multiple organs including the brain, especially the hippocampus that plays an important role in learning and memory. Silibinin, a natural flavonoid derived from… read more here.
Keywords: overtrained rats; memory defects; senescence; learning memory ... See more keywords
Role of silibinin in the management of diabetes mellitus and its complications
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Pharmacal Research"
DOI: 10.1007/s12272-018-1047-x
Abstract: Diabetes mellitus is globally approaching epidemic proportions and acts as a major cause of a number of serious health problems diagnosed as diabetic complications. The current oral drugs in the treatment of diabetes and its… read more here.
Keywords: diabetes mellitus; silibinin; role silibinin; diabetic complications ... See more keywords
Cytotoxic and Antitumor Activity of Liposomal Silibinin
Sign Up to like & getrecommendations! Published in 2018 at "BioNanoScience"
DOI: 10.1007/s12668-018-0556-x
Abstract: The cytotoxic and antitumor effect of liposomal form of silibinin was studied. It was shown that the liposomal silibinin reveals more pronounced cytotoxic activity in vitro against HeLa (cervix carcinoma), HT1080 (fibrosarcoma), and MCF-7 (breast… read more here.
Keywords: silibinin; cytotoxic antitumor; liposomal silibinin; antitumor activity ... See more keywords
Co-encapsulation of collagenase type I and silibinin in chondroitin sulfate coated multilayered nanoparticles for targeted treatment of liver fibrosis.
Sign Up to like & getrecommendations! Published in 2021 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2021.117964
Abstract: Components of the extracellular matrix (ECM) are overexpressed in fibrotic liver. Collagen is the main component of the liver fibrosis stroma. Here we demonstrate that chondroitin sulfate coated multilayered 50-nm nanoparticles encapsulating collagenase and silibinin… read more here.
Keywords: silibinin; chondroitin sulfate; fibrosis; liver ... See more keywords
Silibinin to improve cancer therapeutic, as an apoptotic inducer, autophagy modulator, cell cycle inhibitor, and microRNAs regulator
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.10.009
Abstract: &NA; Silibinin is a natural plant polyphenol with high antioxidant and anticancer properties, which causes broad‐spectrum efficacy against cancer, including cell cycle arrest and apoptosis in most cancer cell types. Silibinin, by modulating the apoptosis,… read more here.
Keywords: cell cycle; cancer; modulator; cell ... See more keywords
Magnetic-core-based silibinin nanopolymeric carriers for the treatment of renal cell cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119377
Abstract: AIMS Silibinin offers potential anticancer effect with less aqueous solubility and high permeability. The present study aimed to develop biocompatible magnetic-core-based nanopolymeric carriers of poly (D, l-lactide-co-glycolic) acid (PLGA) encapsulated silibinin for the sustained release… read more here.
Keywords: magnetic core; core based; silibinin; based silibinin ... See more keywords
122. Silibinin regulates the NF-κB pathway and NLRP1/NLRP3 inflammasomes induced by monosodium urate in monocytes from preeclamptic women and THP-1 cells
Sign Up to like & getrecommendations! Published in 2018 at "Pregnancy Hypertension"
DOI: 10.1016/j.preghy.2018.08.237
Abstract: Introduction Preeclampsia (PE) is characterized by a state of abnormal activation of the innate immune system. It’s associated with hyperuricemia and elevated serum levels of inflammatory cytokines. Uric acid crystals can activate inflammasome, a multiprotein… read more here.
Keywords: preeclamptic women; inflammatory cytokines; nlrp1 nlrp3; silibinin ... See more keywords
Family 1 Glycosyltransferase UGT706F8 from Zea mays Selectively Catalyzes the Synthesis of Silibinin 7-O-β-d-Glucoside
Sign Up to like & getrecommendations! Published in 2022 at "ACS Sustainable Chemistry & Engineering"
DOI: 10.1021/acssuschemeng.1c07593
Abstract: Regioselective glycosylation is a chemical challenge, leading to multistep syntheses with protecting group manipulations, ultimately resulting in poor atom economy and compromised sustainability. Enzymes allow eco-friendly and regioselective bond formation with fully deprotected substrates in… read more here.
Keywords: mays selectively; synthesis silibinin; glycosyltransferase; family glycosyltransferase ... See more keywords