Krill oil and low-dose aspirin combination mitigates experimentally induced silicosis in rats: role of NF-κB/TGF-β1/MMP-9 pathway
Sign Up to like & getrecommendations! Published in 2021 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-020-11921-7
Abstract: This study is an attempt to assess pulmonary protective and antifibrotic potentials of a combination of aspirin, a widely used anti-inflammatory and cardioprotective agent, and krill oil, a naturally occurring omega-3 fatty acid source, against… read more here.
Keywords: aspirin; combination; krill oil; silica induced ... See more keywords
Aberrant expression of miR-125a-3p promotes fibroblast activation via Fyn/STAT3 pathway during silica-induced pulmonary fibrosis.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology"
DOI: 10.1016/j.tox.2019.01.007
Abstract: Various miRNAs are dysregulated during initiation and progression of pulmonary fibrosis. However, their function remains limited in silicosis. Here, we observed that miR-125a-3p was downregulated in silica-induced fibrotic murine lung tissues. Ectopic miR-125a-3p expression with… read more here.
Keywords: fibrosis; silica induced; expression; pulmonary fibrosis ... See more keywords
Inhibition of MARCO ameliorates silica-induced pulmonary fibrosis by regulating epithelial-mesenchymal transition.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2018.10.031
Abstract: Epithelial-mesenchymal transition (EMT) is linked to fibrosis following exposure to silica. The scavenger receptor, macrophage receptor with collagenous structure (MARCO) plays an important role in silica-induced inflammation, however, the effect of MARCO on silica-induced fibrosis… read more here.
Keywords: mesenchymal transition; fibrosis; marco; silica induced ... See more keywords
Gas6 or Mer deficiency ameliorates silica-induced autophagosomes accumulation in mice lung.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2020.11.013
Abstract: Published evidences have shown that autophagy plays an important role in silica-induced lung inflammation and collagen deposition. Our previous study found that the level of growth arrest-specific protein 6 (Gas6) in bronchoalveolar lavage fluid was… read more here.
Keywords: gas6; autophagosomes accumulation; mer; silica induced ... See more keywords
High-fat western diet-consumption alters crystalline silica-induced serum adipokines, inflammatory cytokines and arterial blood flow in the F344 rat
Sign Up to like & getrecommendations! Published in 2022 at "Toxicology Reports"
DOI: 10.1016/j.toxrep.2021.12.001
Abstract: Highlights • Silica reduced serum leptin and adiponectin, no effects on body or fat pad weight.• HFWD-consumption altered pro-inflammatory cytokines in silica-exposed animals.• Silica altered pulse frequency; HFWD increased mean blood flow; effects additive.• HFWD… read more here.
Keywords: blood flow; inflammatory cytokines; silica; silica induced ... See more keywords
Silica-induced electron loss of silver nanoparticles.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d1nr05884c
Abstract: Despite the frequent use of silver nanoparticles (Ag NPs) embedded in materials for medical or optical applications, the effect of the matrix on the nanoparticle properties remains largely unknown. This study aims to shed light… read more here.
Keywords: induced electron; electron loss; silver; silver nanoparticles ... See more keywords
Kaempferol Modulates Autophagy and Alleviates Silica-Induced Pulmonary Fibrosis.
Sign Up to like & getrecommendations! Published in 2019 at "DNA and cell biology"
DOI: 10.1089/dna.2019.4941
Abstract: Silicosis is an occupational disease characterized as inflammatory cells infiltration and severe progressive pulmonary fibrosis. Kaempferol (Kae), a flavonoid exists in many plants and fruits, has been proved to have anti-inflammatory and antifibrosis functions. However,… read more here.
Keywords: silicosis; induced pulmonary; silica induced; pulmonary fibrosis ... See more keywords
Adenoviral Transduction of Dickkopf-1 Alleviates Silica-induced Silicosis Development in Lungs of Mice.
Sign Up to like & getrecommendations! Published in 2021 at "Human gene therapy"
DOI: 10.1089/hum.2021.008
Abstract: Silicosis is an occupational disease caused by inhalation of silica dust, which is hallmarked by progressive pulmonary fibrosis associated with poor prognosis. Wnt/β-catenin signaling is implicated in the development of fibrosis and is a therapeutic… read more here.
Keywords: wnt catenin; silicosis; silica induced; transduction ... See more keywords
Silica-induced fibrosis: an ancient response from the early metazoans
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Experimental Biology"
DOI: 10.1242/jeb.166405
Abstract: ABSTRACT Exposure to crystalline silica particles causes silicosis, an occupational disease leading to an overproduction of collagen in the lung. The first step of this pathology is characterized by the release of inflammatory mediators. Tumour… read more here.
Keywords: collagen; response; silica; silica induced ... See more keywords
Role of a novel immune modulating DDR2-expressing population in silica-induced pulmonary fibrosis
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0180724
Abstract: Micro-injuries associated with chronic inhaled particle exposures are linked with activation of the immune response and are thought to contribute to progression of fibrotic disease. In the pulmonary environment, we have previously demonstrated a heterogeneous… read more here.
Keywords: novel; fibrosis; induced pulmonary; silica induced ... See more keywords
Metformin Attenuates Silica-Induced Pulmonary Fibrosis by Activating Autophagy via the AMPK-mTOR Signaling Pathway
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.719589
Abstract: Long-term exposure to crystalline silica particles leads to silicosis characterized by persistent inflammation and progressive fibrosis in the lung. So far, there is no specific treatment to cure the disease other than supportive care. In… read more here.
Keywords: fibrosis; fibrosis activating; induced pulmonary; silica induced ... See more keywords