In silico analysis and experimental validation to exhibit anti-nasopharyngeal carcinoma effects of plumbagin, an anti-cancer compound.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.11900
Abstract: BACKGROUND Nasopharyngeal carcinoma (NPC) is publicly known as a malignant tumor. Our previous study reports plumbagin exhibiting potent anti-cancer actions. Howbeit, more mechanical details of plumbagin against NPC remain untapped. Here, our study aimed to… read more here.
Keywords: nasopharyngeal carcinoma; experimental validation; validation; silico analysis ... See more keywords
In silico analysis of structural modifications in and around the integrin αIIb genu caused by ITGA2B variants in human platelets with emphasis on Glanzmann thrombasthenia
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.365
Abstract: Studies on the inherited bleeding disorder, Glanzmann thrombasthenia (GT), have helped define the role of the αIIbβ3 integrin in platelet aggregation. Stable bent αIIbβ3 undergoes conformation changes on activation allowing fibrinogen binding and its taking… read more here.
Keywords: glanzmann thrombasthenia; silico analysis; iib genu; iib ... See more keywords
In Silico Analysis of Class III Peroxidases: Hypothetical Structure, Ligand Binding Sites, Posttranslational Modifications, and Interaction with Substrates.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0528-8_24
Abstract: Functional analyses of peroxidases are a major challenge. In silico analysis appears to be a powerful tool to overcome at least some of the problems that arose from (1) the numerous possible functions of peroxidases,… read more here.
Keywords: analysis; class iii; silico analysis; binding sites ... See more keywords
Molecular Characterization of a Vector-Based Candidate Antigen Using the 3'-RACE and Genome Walking Methods and In Silico Analysis of the Correspondent Protein for Vaccine Design and Development.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1884-4_29
Abstract: The main objectives of developing vaccines to prevent malaria transmission are malaria control and preventing the reemergence of the disease in endemic regions. Molecular and in silico characterization of a candidate molecule is the first… read more here.
Keywords: characterization; genome walking; vaccine design; race genome ... See more keywords
In Vitro and In Silico Analysis of Ascorbic Acid Towards Lanosterol 14-α-Demethylase Enzyme of Fluconazole-Resistant Candida albicans
Sign Up to like & getrecommendations! Published in 2020 at "Current Microbiology"
DOI: 10.1007/s00284-020-02269-9
Abstract: Antibiotic resistance is one of the major concerns and the biggest threats to the world population. The incidents of antibiotic resistance in Candida spp. were frequently recorded. In the present investigation, antifungal potential of ascorbic… read more here.
Keywords: analysis; silico analysis; ascorbic acid; vitro silico ... See more keywords
In Silico Analysis for Determination and Validation of Iron-Regulated Protein from Escherichia coli
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-018-9797-3
Abstract: The iron ion is an essential element in biological processes. Many of biological activities in cells, such as peroxide reduction, nucleotide biosynthesis, and electron transport, are helped via iron ions. Extra-intestinal localities have few iron… read more here.
Keywords: analysis determination; silico analysis; coli; iron regulated ... See more keywords
In Silico Analysis of New Potent Anti-hyperglycemic Molecule for Diabetes Type 2 Management
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-019-09905-4
Abstract: Abstract Diabetes mellitus Type 2 happens to be one of the most challenging health concerns in recent times and has spiked an alarming rise taking it into epidemic category. For management of this epidemic, sulphonylureas… read more here.
Keywords: molecule; silico analysis; management; diabetes type ... See more keywords
In silico analysis of microRNA genes in azoospermia factor Y-chromosome microdeletions
Sign Up to like & getrecommendations! Published in 2022 at "International Urology and Nephrology"
DOI: 10.1007/s11255-022-03133-4
Abstract: Microdeletion on Y-chromosome is a well-known genetic cause of infertility in azoospermic and oligozoospermic men. RNA transcripts possess microRNA (miRNA) response elements (MRE) that may interact with competing endogenous RNAs (ceRNA), thus repressing their activity.… read more here.
Keywords: azf locus; silico analysis; chromosome; azoospermia factor ... See more keywords
In Silico Analysis of the Biodiversity and Conservation Status of Mitochondrial Cytochrome C Oxidase Subunit 1 (CO1) Gene of Taenia multiceps
Sign Up to like & getrecommendations! Published in 2020 at "Acta Parasitologica"
DOI: 10.1007/s11686-020-00236-9
Abstract: Taenia multiceps resides in the small intestine of carnivores such as dogs, foxes, woles, jackals, while Coenurus cerebralis which is the larval form usually settle in the central nervous system and spinal cord of intermediate… read more here.
Keywords: sheep isolates; analysis; silico analysis; taenia multiceps ... See more keywords
Implication of OPRM1 A118G Polymorphism in Opioids Addicts in Pakistan: In vitro and In silico Analysis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-018-1123-1
Abstract: Single nucleotide polymorphism in OPRM1 gene is associated with hedonic and reinforcing consequences of opioids. Risk and protective alleles may vary in different populations. One hundred healthy controls and 100 opioids (predominantly heroin) addicts from… read more here.
Keywords: oprm1 a118g; silico analysis; polymorphism; implication oprm1 ... See more keywords
A comprehensive in silico analysis of sortase superfamily
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Microbiology"
DOI: 10.1007/s12275-019-8545-5
Abstract: Sortases are cysteine transpeptidases that assemble surface proteins and pili in their cell envelope. Encoded by all Gram-positive bacteria, few Gram-negative bacteria and archaea, sortases are currently divided into six classes (A-F). Due to the… read more here.
Keywords: comprehensive silico; class; analysis sortase; analysis ... See more keywords