In vitro and in silico assessment of DNA interaction, topoisomerase I and II inhibition properties of chrysosplenetin.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.07.049
Abstract: Chrysosplenetin is a methoxyflavone with reported anti-cancer effect. We tested its cytotoxic effect on the MCF-7 breast cancer cell line, and determined its effect on DNA intercalation and on the activity of topoisomerases I and… read more here.
Keywords: topoisomerase inhibition; dna; vitro silico; topoisomerase ... See more keywords
In silico assessment of the effects of various compounds in MEA/hiPSC-CM assays: Modeling and numerical simulations.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of pharmacological and toxicological methods"
DOI: 10.1016/j.vascn.2017.10.005
Abstract: We propose a mathematical approach for the analysis of drugs effects on the electrical activity of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) based on multi-electrode array (MEA) experiments. Our goal is to produce an… read more here.
Keywords: hipsc assays; mea hipsc; assessment effects; silico assessment ... See more keywords
In Silico Assessment of the Lipid Fingerprint Signature of ATP2, the Essential P4-ATPase of Malaria Parasites
Sign Up to like & getrecommendations! Published in 2022 at "Membranes"
DOI: 10.3390/membranes12070702
Abstract: ATP2, a putative type 4 P-type ATPase, is a phosphatidylinositol-4-phosphate (PI4P)-regulated phospholipid transporter with an interesting potential as an antimalarial drug target due to its conservation across Plasmodium species and its essential role in the… read more here.
Keywords: assessment lipid; atpase; fingerprint signature; silico assessment ... See more keywords