In silico comparative analysis of KRAS mutations at codons 12 and 13: Structural modifications of P-Loop, switch I&II regions preventing GTP hydrolysis
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DOI: 10.1016/j.compbiomed.2021.105110
Abstract: KRAS mutation is prevalent in around 30% of all cancers and is an undruggable molecular target. Of seven mutations at codon 12 and 13, only one, the G12C mutant is finally proven to be druggable,… read more here.
Keywords: silico comparative; comparative analysis; gtp; analysis kras ... See more keywords