In silico comparative analysis of KRAS mutations at codons 12 and 13: Structural modifications of P-Loop, switch I&II regions preventing GTP hydrolysis
Sign Up to like & getrecommendations! Published in 2022 at "Computers in biology and medicine"
DOI: 10.1016/j.compbiomed.2021.105110
Abstract: KRAS mutation is prevalent in around 30% of all cancers and is an undruggable molecular target. Of seven mutations at codon 12 and 13, only one, the G12C mutant is finally proven to be druggable,… read more here.
Keywords: silico comparative; comparative analysis; gtp; analysis kras ... See more keywords
Phytochelatin Synthase: An In Silico Comparative Analysis in Cyanobacteria and Eukaryotic Microalgae
Sign Up to like & getrecommendations! Published in 2024 at "Plants"
DOI: 10.3390/plants13152165
Abstract: Phytochelatins (PCs) are small cysteine-rich peptides involved in metal detoxification, not genetically encoded but enzymatically synthesized by phytochelatin synthases (PCSs) starting from glutathione. The constitutive PCS expression even in the absence of metal contamination, the… read more here.
Keywords: cyanobacteria eukaryotic; synthase silico; phytochelatin synthase; comparative analysis ... See more keywords