In Silico-Driven THIOMAB Approach for Stable PROTAC Conjugates by Docking Payloads in Antibody Cavities.
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DOI: 10.1021/acs.bioconjchem.4c00588
Abstract: The heterobifunctional proteolysis targeting chimeras (PROTACs) are a class of emerging therapeutic modalities that enable selective degradation of target proteins in cells. As antibody payloads, they offer several advantages compared to conventional chemical toxins, such… read more here.
Keywords: protac; antibody; thiomab approach; silico driven ... See more keywords
In silico-driven identification of novel molluscicides effective against Biomphalaria glabrata (Say, 1818)
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DOI: 10.1039/d0nj03314f
Abstract: Schistosomiasis control in endemic areas depends on several factors, including mass drug delivery programs and interrupting the transmission of disease by controlling the intermediate host snails in the freshwater ecosystem using molluscicides. However, the use… read more here.
Keywords: driven identification; biomphalaria glabrata; identification novel; silico driven ... See more keywords