In silico drug repurposing for filarial infection predicts nilotinib and paritaprevir as potential inhibitors of the Wolbachia 5′-aminolevulinic acid synthase
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-87976-4
Abstract: Filarial infections affect millions of individuals and are responsible for some notorious disabilities. Current treatment options involve repeated mass drug administrations, which have been met with several challenges despite some successes. Administration of doxycycline, an… read more here.
Keywords: silico drug; drug repurposing; aminolevulinic acid; drug ... See more keywords
Freely Accessible Chemical Database Resources of Compounds for in Silico Drug Discovery.
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DOI: 10.2174/0929867325666180508100436
Abstract: BACKGROUND In silico drug discovery has been proved to be a solidly established key component in early drug discovery. However, this task is hampered by the limitation of quantity and quality of compound databases for… read more here.
Keywords: silico drug; freely accessible; drug; database ... See more keywords
In silico Drug Screening Approach Using L1000-Based Connectivity Map and Its Application to COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.842641
Abstract: Conventional drug screening methods search for a limited number of small molecules that directly interact with the target protein. This process can be slow, cumbersome and has driven the need for developing new drug screening… read more here.
Keywords: drug screening; l1000 based; expression; drug ... See more keywords
In Silico Drug Prescription for Targeting Cancer Patient Heterogeneity and Prediction of Clinical Outcome
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DOI: 10.3390/cancers11091361
Abstract: In silico drug prescription tools for precision cancer medicine can match molecular alterations with tailored candidate treatments. These methodologies require large and well-annotated datasets to systematically evaluate their performance, but this is currently constrained by… read more here.
Keywords: silico drug; drug; cancer; drug prescription ... See more keywords
In Silico Drug Repurposing in Multiple Sclerosis Using scRNA-Seq Data
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24020985
Abstract: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system still lacking a cure. Treatment typically focuses on slowing the progression and managing MS symptoms. Single-cell transcriptomics allows the investigation of the immune… read more here.
Keywords: multiple sclerosis; drug repurposing; single cell; drug ... See more keywords
β-Secretase-1: In Silico Drug Reposition for Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24098164
Abstract: The β-secretase-1 enzyme (BACE-1) performs a key role in the production of beta-Amyloid protein (Aβ), which is associated with the development of Alzheimer’s disease (AD). The inhibition of BACE-1 has been an important pharmacological strategy… read more here.
Keywords: disease; alzheimer disease; secretase silico; treatment ... See more keywords
In Silico Drug Repurposing Framework Predicts Repaglinide, Agomelatine and Protokylol as TRPV1 Modulators with Analgesic Activity
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14122563
Abstract: Pain is one of the most common symptoms experienced by patients. The use of current analgesics is limited by low efficacy and important side effects. Transient receptor potential vanilloid-1 (TRPV1) is a non-selective cation channel,… read more here.
Keywords: agonists antagonists; framework; activity; trpv1 ... See more keywords