Synthesis, in vivo and in silico evaluation of novel 2,3‐dihydroquinazolin‐4(1H)‐one derivatives as potential anticonvulsant agents
Sign Up to like & getrecommendations! Published in 2019 at "Drug Development Research"
DOI: 10.1002/ddr.21506
Abstract: In light of the pharmacophoric structural requirements for achieving anticonvulsant activity, a series of N‐(1‐methyl‐4‐oxo‐2‐un/substituted‐1,2‐dihydroquinazolin‐3[4H]‐yl)benzamide (4a‐g) and N‐(1‐methyl‐4‐oxo‐2‐un/substituted‐1,2‐dihydroquinazolin‐3[4H]‐yl)‐2‐phenylacetamide (4h‐n) derivatives were synthesized in two steps starting from the reaction of N‐methyl isatoic anhydride with the… read more here.
Keywords: vivo silico; synthesis vivo; evaluation novel; dihydroquinazolin one ... See more keywords
In silico evaluation of arrhythmia
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DOI: 10.1016/j.cophys.2017.11.003
Abstract: Iteration between computational and experimental physiology has largely contributed to expanding scientific knowledge in cardiovascular research over the last decades. In this article, we briefly review key progress in cardiac modeling for the understanding of… read more here.
Keywords: evaluation arrhythmia; physiology; silico; silico evaluation ... See more keywords
In vitro and in silico evaluation of antimicrobial properties of Delphinium cashmerianum L., a medicinal herb growing in Kashmir, India.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2022.115046
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Microorganisms are developing resistance to synthetic drugs. As a result, the search for novel antimicrobial compounds has become an urgent need. Medicinal plants are commonly used as traditional medicine and Delphinium is one… read more here.
Keywords: streptococcus pneumonia; ethyl acetate; vitro silico; silico evaluation ... See more keywords
In silico evaluation of flavonoids as effective antiviral agents on the spike glycoprotein of SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2021 at "Saudi Journal of Biological Sciences"
DOI: 10.1016/j.sjbs.2020.11.049
Abstract: The novel coronavirus pandemic has spread over in 213 countries as of July 2020. Approximately 12 million people have been infected so far according to the reports from World Health Organization (WHO). Preventive measures are… read more here.
Keywords: protein; novel coronavirus; spike protein; silico evaluation ... See more keywords
In Silico Evaluation of Nonsynonymous SNPs in Human ADAM33: The Most Common Form of Genetic Association to Asthma Susceptibility
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/1089722
Abstract: ADAM33 is a zinc-dependent metalloprotease of the ADAM family, which plays a vital biological role as an activator of Th2 cytokines and growth factors. Moreover, this protein is crucial for the normal development of the… read more here.
Keywords: nonsynonymous snps; asthma; evaluation nonsynonymous; silico evaluation ... See more keywords
Experimental and In Silico Evaluation of New Heteroaryl Benzothiazole Derivatives as Antimicrobial Agents
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DOI: 10.3390/antibiotics11111654
Abstract: In this manuscript, we describe the design, preparation, and studies of antimicrobial activity of a series of novel heteroarylated benzothiazoles. A molecular hybridization approach was used for the designing compounds. The in vitro evaluation exposed… read more here.
Keywords: evaluation; heteroaryl benzothiazole; evaluation new; new heteroaryl ... See more keywords
In Silico Evaluation of Antifungal Compounds from Marine Sponges against COVID-19-Associated Mucormycosis
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DOI: 10.3390/md20030215
Abstract: The world is already facing the devastating effects of the SARS-CoV-2 pandemic. A disseminated mucormycosis epidemic emerged to worsen this situation, causing havoc, especially in India. This research aimed to perform a multitargeted docking study… read more here.
Keywords: compounds marine; antifungal compounds; marine sponges; mucormycosis ... See more keywords
In Silico Evaluation of Natural Flavonoids as a Potential Inhibitor of Coronavirus Disease
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27196374
Abstract: The recent coronavirus disease (COVID-19) outbreak in Wuhan, China, has led to millions of infections and the death of approximately one million people. No targeted therapeutics are currently available, and only a few efficient treatment… read more here.
Keywords: coronavirus disease; coronavirus; natural flavonoids; evaluation natural ... See more keywords