In-silico gene essentiality analysis of polyamine biosynthesis reveals APRT as a potential target in cancer
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DOI: 10.1038/s41598-017-14067-8
Abstract: Constraint-based modeling for genome-scale metabolic networks has emerged in the last years as a promising approach to elucidate drug targets in cancer. Beyond the canonical biosynthetic routes to produce biomass, it is of key importance… read more here.
Keywords: biosynthesis; gene essentiality; silico gene; cancer ... See more keywords