Validated In Silico Model for Biofilm Formation in Escherichia coli.
Sign Up to like & getrecommendations! Published in 2022 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.1c00445
Abstract: Using Escherichia coli as the representative biofilm former, we report here the development of an in silico model built by simulating events that transform a free-living bacterial entity into self-encased multicellular biofilms. Published literature on… read more here.
Keywords: escherichia coli; silico model; biofilm formation; model ... See more keywords
An in silico model to study the impact of carbonic anhydrase IX expression on tumour growth and anti-PD-1 therapy
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the Royal Society Interface"
DOI: 10.1098/rsif.2022.0654
Abstract: Immune checkpoint inhibitors (ICIs) are revolutionary cancer treatments. However, the mechanisms behind their effectiveness are not yet fully understood. Here, we aimed to investigate the role of the pH-regulatory enzyme carbonic anhydrase IX (CAIX) in… read more here.
Keywords: carbonic anhydrase; caix; expression; silico model ... See more keywords
A Validated Multiscale In-Silico Model for Mechano-sensitive Tumour Angiogenesis and Growth
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DOI: 10.1371/journal.pcbi.1005259
Abstract: Vascularisation is a key feature of cancer growth, invasion and metastasis. To better understand the governing biophysical processes and their relative importance, it is instructive to develop physiologically representative mathematical models with which to compare… read more here.
Keywords: silico model; multiscale silico; angiogenesis; mechano sensitive ... See more keywords
In Silico Model for Chemical-Induced Chromosomal Damages Elucidates Mode of Action and Irrelevant Positives
Sign Up to like & getrecommendations! Published in 2020 at "Genes"
DOI: 10.3390/genes11101181
Abstract: In silico tools to predict genotoxicity have become important for high-throughput screening of chemical substances. However, current in silico tools to evaluate chromosomal damage do not discriminate in vitro-specific positives that can be followed by… read more here.
Keywords: silico model; model chemical; model; chromosomal damages ... See more keywords