A pilot in-silico modeling-based study of the pathological effects on the biomechanical function of tricuspid valves.
Sign Up to like & getrecommendations! Published in 2020 at "International journal for numerical methods in biomedical engineering"
DOI: 10.1002/cnm.3346
Abstract: Current clinical assessment of functional tricuspid valve regurgitation relies on metrics quantified from medical imaging modalities. Although these clinical methodologies are generally successful, the lack of detailed information about the mechanical environment of the valve… read more here.
Keywords: silico modeling; modeling based; study; biomechanical function ... See more keywords
In Silico Modeling and Simulation to Guide Bioequivalence Testing for Oral Drugs in a Virtual Population
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Pharmacokinetics"
DOI: 10.1007/s40262-021-01045-7
Abstract: Model-informed drug discovery and development (MID3) shows great advantages in facilitating drug development. A physiologically based pharmacokinetic model is one of the powerful computational approaches of MID3, and the emerging field of virtual bioequivalence is… read more here.
Keywords: bioequivalence; virtual bioequivalence; oral drugs; silico modeling ... See more keywords
In vitro and in silico modeling of endovascular stroke treatments for acute ischemic stroke.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biomechanics"
DOI: 10.1016/j.jbiomech.2021.110693
Abstract: Acute ischemic stroke occurs when a thrombus obstructs a cerebral artery, leading to sub-optimal blood perfusion to brain tissue. A recently developed, preventive treatment is the endovascular stroke treatment (EVT), which is a minimally invasive… read more here.
Keywords: endovascular stroke; ischemic stroke; silico modeling; vitro silico ... See more keywords
Toward in Silico Modeling of Dynamic Combinatorial Libraries
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DOI: 10.1021/acscentsci.2c00048
Abstract: Dynamic combinatorial libraries (DCLs) display adaptive behavior, enabled by the reversible generation of their molecular constituents from building blocks, in response to external effectors, e.g., protein receptors. So far, chemoinformatics has not yet been used… read more here.
Keywords: dynamic combinatorial; modeling dynamic; combinatorial libraries; toward silico ... See more keywords
In Silico Modeling and Docking Analysis of CTX-M-5, Cefotaxime-Hydrolyzing β-Lactamase from Human-Associated Salmonella Typhimurium
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Pharmacology and Pharmacotherapeutics"
DOI: 10.1177/0976500x221109721
Abstract: Objective: To computationally model the CTX-M-5 β-lactamase and establish its structure, which is exclusively present in human-associated Salmonella. Methods: The CTX-M-5 aminoacid sequence (Uniprot ID:O65975) of Salmonella enterica subsp. enterica serovar typhimurium was retrieved from… read more here.
Keywords: salmonella; associated salmonella; silico modeling; typhimurium ... See more keywords