In Silico Models for Hepatotoxicity.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1960-5_14
Abstract: In this chapter, we review the state of the art of predicting human hepatotoxicity using in silico techniques. There has been significant progress in this area over the past 20 years but there are still some… read more here.
Keywords: biology; models hepatotoxicity; silico models; hepatotoxicity ... See more keywords
Development, validation and integration of in silico models to identify androgen active chemicals.
Sign Up to like & getrecommendations! Published in 2019 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2018.12.131
Abstract: Humans are exposed to large numbers of environmental chemicals, some of which potentially interfere with the endocrine system. The identification of potential endocrine disrupting chemicals (EDCs) has gained increasing priority in the assessment of environmental… read more here.
Keywords: silico models; development validation; integration silico; identify androgen ... See more keywords
Mixtures-Inclusive In Silico Models of Ocular Toxicity Based on United States and International Hazard Categories.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.1c00443
Abstract: Computational modeling grounded in reliable experimental data can help design effective non-animal approaches to predict the eye irritation and corrosion potential of chemicals. The National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative… read more here.
Keywords: toxicology; inclusive silico; models ocular; silico models ... See more keywords
Environmental Hazard Screening of Heterocyclic Polyaromatic Hydrocarbons: Physicochemical Data and In Silico Models.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental science & technology"
DOI: 10.1021/acs.est.2c06915
Abstract: Heterocyclic polyaromatic hydrocarbons (heterocyclic PAHs) are frequently found in the environment yet, compared to homocyclic PAHs, little attention has been paid to their environmental behavior and a comprehensive hazard assessment has not been undertaken. Surprisingly,… read more here.
Keywords: heterocyclic polyaromatic; silico models; polyaromatic hydrocarbons; environmental hazard ... See more keywords
In silico models to predict tubular secretion or reabsorption clearance pathway using physicochemical properties and structural characteristics
Sign Up to like & getrecommendations! Published in 2022 at "Xenobiotica"
DOI: 10.1080/00498254.2022.2076632
Abstract: Abstract Renal clearance is one of the main pathways for a drug to be cleared from plasma. The aim of this study is to develop in-silico models to find out the relationship between the type… read more here.
Keywords: clearance; reabsorption; tubular secretion; silico models ... See more keywords
Ontogenetic and in silico models of spatial‐packing in the hypermuscular mouse skull
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Anatomy"
DOI: 10.1111/joa.13393
Abstract: Networks linking single genes to multiple phenotypic outcomes can be founded on local anatomical interactions as well as on systemic factors like biochemical products. Here we explore the effects of such interactions by investigating the… read more here.
Keywords: silico models; skull; ontogenetic silico; models spatial ... See more keywords
In Silico Models for Nanomedicine: Recent Developments.
Sign Up to like & getrecommendations! Published in 2018 at "Current medicinal chemistry"
DOI: 10.2174/0929867324666170417120725
Abstract: Nanomedicine is a recent promising setting for the advancement of current medical therapies, in particular for cancer. Nanoparticle-mediated therapies are aimed to tackle extremely complex phenomena, involving different biochemical, mechanical and biophysical factors. Computational models… read more here.
Keywords: silico models; models nanomedicine; recent developments; chemistry ... See more keywords
In Vitro, In Vivo, and In Silico Models of Lymphangiogenesis in Solid Malignancies
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DOI: 10.3390/cancers14061525
Abstract: Simple Summary Lymphangiogenesis is the formation of new lymphatic vessels in physiological conditions but has also been found to be associated with pathologies. For example, it has been proven to be involved in cancer progression… read more here.
Keywords: vitro vivo; lymphangiogenesis; silico models; lymphatic vessels ... See more keywords