MutateX: an automated pipeline for in silico saturation mutagenesis of protein structures and structural ensembles
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac074
Abstract: Mutations, which result in amino acid substitutions, influence the stability of proteins and their binding to biomolecules. A molecular understanding of the effects of protein mutations is both of biotechnological and medical relevance. Empirical free… read more here.
Keywords: automated pipeline; saturation mutagenesis; silico saturation; protein ... See more keywords
fastISM: Performant in-silico saturation mutagenesis for convolutional neural networks.
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btac135
Abstract: MOTIVATION Deep learning models such as convolutional neural networks are able to accurately map biological sequences to associated functional readouts and properties by learning predictive de novo representations. In-silico saturation mutagenesis (ISM) is a popular… read more here.
Keywords: saturation mutagenesis; neural networks; fastism; convolutional neural ... See more keywords