In Silico Screen and Structural Analysis Identifies Bacterial Kinase Inhibitors which Act with β-Lactams To Inhibit Mycobacterial Growth.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.8b00905
Abstract: New tools and concepts are needed to combat antimicrobial resistance. Actinomycetes and firmicutes share several eukaryotic-like Ser/Thr kinases (eSTK) that offer antibiotic development opportunities, including PknB, an essential mycobacterial eSTK. Despite successful development of potent… read more here.
Keywords: kinase inhibitors; screen structural; silico screen; pknb ... See more keywords
In Silico Screen Identifies a New Family of Agonists for the Bacterial Mechanosensitive Channel MscL
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DOI: 10.3390/antibiotics11040433
Abstract: MscL is a highly conserved mechanosensitive channel found in the majority of bacterial species, including pathogens. It functions as a biological emergency release valve, jettisoning solutes from the cytoplasm upon acute hypoosmotic stress. It opens… read more here.
Keywords: mscl; mechanosensitive channel; silico screen; channel ... See more keywords