Combinatorial In Silico Strategy towards Identifying Potential Hotspots during Inhibition of Structurally Identical HDAC1 and HDAC2 Enzymes for Effective Chemotherapy against Neurological Disorders
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DOI: 10.3389/fnmol.2017.00357
Abstract: Histone deacetylases (HDACs) regulate epigenetic gene expression programs by modulating chromatin architecture and are required for neuronal development. Dysregulation of HDACs and aberrant chromatin acetylation homeostasis have been implicated in various diseases ranging from cancer… read more here.
Keywords: hdac2; hdac2 enzymes; combinatorial silico; silico strategy ... See more keywords