Degradation Pathway Proposal, Structure Elucidation, and In Silico Toxicity Prediction of Dapagliflozin Propane Diol Hydrolytic Degradation Products
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DOI: 10.1007/s10337-020-03938-4
Abstract: Dapagliflozin (DAP) is therapeutic agent for diabetes mellitus type II patients with insufficient glycemic control by exercise and diet. Stability-indicating LC–MS method was developed and validated on C8 column and method was able to separate… read more here.
Keywords: degradation; structure elucidation; hydrolytic degradation; silico toxicity ... See more keywords
Docking and in silico toxicity assessment of Arthrospira compounds as potential antiviral agents against SARS-CoV-2
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DOI: 10.1007/s10811-021-02372-9
Abstract: A race is currently being launched as a result of the international health situation. This race aims to find, by various means, weapons to counter the Covid-19 pandemic now widespread on all continents. The aquatic… read more here.
Keywords: docking silico; assessment arthrospira; toxicity; silico toxicity ... See more keywords
Complementary HPLC, in silico toxicity, and molecular docking studies for investigation of the potential influences of gastric acidity and nitrite content on paracetamol safety
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DOI: 10.1016/j.microc.2019.104107
Abstract: Abstract This study was initiated for investigating the possible gastro-transformations that may affect the integrity and safety of the most commonly administered analgesic and antipyretic, paracetamol (PCM). Revisiting the safety of PCM has been accomplished… read more here.
Keywords: silico toxicity; pcm; toxicity; molecular docking ... See more keywords
Tyrosinase Inhibitory Ability and In Vitro, In Vivo Acute Oral and In Silico Toxicity Evaluation of Extracts Obtained from Algerian Fir (Abiesnumidica de Lannoy ex CARRIERE) Needles
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DOI: 10.3390/plants11182389
Abstract: This study was designed to evaluate the tyrosinase inhibitory effect, in vitro, in vivo, and in silico toxicity of fractions isolated from A. numidica de Lannoy needles. The cytotoxicity of extracts was examined against Artemia… read more here.
Keywords: vitro vivo; tyrosinase inhibitory; silico toxicity; toxicity ... See more keywords