In-silico trial emulation to predict the cardiovascular protection of new lipid-lowering drugs: an illustration through the design of the SIRIUS programme.
Sign Up to like & getrecommendations! Published in 2024 at "European journal of preventive cardiology"
DOI: 10.1093/eurjpc/zwae254
Abstract: INTRODUCTION Inclisiran, an siRNA targeting hepatic PCSK9 mRNA, administered twice-yearly (after initial and 3-month doses), substantially and sustainably reduced LDL-cholesterol (LDL-C) in Phase III trials. Whether lowering LDL-C with inclisiran translates into a reduced risk… read more here.
Keywords: sirius programme; trial; silico trial; inclisiran ... See more keywords
AI-Assisted in Silico Trial for the Optimization of Osmotherapy After Ischaemic Stroke
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DOI: 10.1109/jbhi.2025.3541004
Abstract: Over the past few decades, osmotherapy has commonly been employed to reduce intracranial pressure in post-stroke oedema. However, evaluating the effectiveness of osmotherapy has been challenging due to the difficulties in clinical intracranial pressure measurement.… read more here.
Keywords: silico trial; intracranial pressure; osmotherapy; assisted silico ... See more keywords
Abstract 4134364: Predicted Low-Density Lipoprotein Cholesterol and Cardiovascular Outcomes Lowering With Inclisiran in Patients With or Without stroke: Insights from SIRIUS in silico trial.
Sign Up to like & getrecommendations! Published in 2024 at "Circulation"
DOI: 10.1161/circ.150.suppl_1.4134364
Abstract: Introduction: Inclisiran, an siRNA, targeting PCSK9 mRNA, reduces LDL-c levels. In SIRIUS in silico trial (NCT05974345), inclisiran was predicted to lower cardiovascular (CV) events in virtual patients with atherosclerotic cardiovascular disease (ASCVD). Research question: This… read more here.
Keywords: silico trial; patients without; placebo; inclisiran ... See more keywords
In silico trial to test COVID-19 candidate vaccines: a case study with UISS platform
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DOI: 10.1186/s12859-020-03872-0
Abstract: Background SARS-CoV-2 is a severe respiratory infection that infects humans. Its outburst entitled it as a pandemic emergence. To get a grip on this outbreak, specific preventive and therapeutic interventions are urgently needed. It must… read more here.
Keywords: sars cov; platform; candidate vaccines; silico trial ... See more keywords