Integrated in silico and in vivo approaches to investigate effects of BDE-99 mediated by the nuclear receptors on developing zebrafish.
Sign Up to like & getrecommendations! Published in 2018 at "Environmental toxicology and chemistry"
DOI: 10.1002/etc.4000
Abstract: One of the most abundant polybrominated diphenyl ethers (PBDEs) is 2,2',4,4',5-pentabromodiphenyl ether (BDE-99), which persists and potentially bioaccumulates in aquatic wildlife. Previous studies in mammals have shown that BDE-99 affects development and disrupts certain endocrine… read more here.
Keywords: nuclear receptors; silico vivo; receptor; mediated nuclear ... See more keywords
Pentachlorophenol affected both reproductive and interrenal systems: In silico and in vivo evidence.
Sign Up to like & getrecommendations! Published in 2017 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2016.09.099
Abstract: The present study investigated the effects on reproductive and interrenal system by pentachlorophenol (PCP) using in silico and in vivo assays. Molecular docking results indicated interacting potency of PCP with steroid receptors (ERα, ERβ, AR, GR)… read more here.
Keywords: silico vivo; reproductive interrenal; evidence; pcp ... See more keywords
In silico and in␣vivo analyses reveal key metabolic pathways enabling the fermentative utilization of glycerol in Escherichia coli.
Sign Up to like & getrecommendations! Published in 2021 at "Microbial biotechnology"
DOI: 10.1111/1751-7915.13938
Abstract: Most microorganisms can metabolize glycerol when external electron acceptors are available (i.e. under respiratory conditions). However, few can do so under fermentative conditions owing to the unique redox constraints imposed by the high degree of… read more here.
Keywords: escherichia coli; glycerol escherichia; silico vivo; glycerol ... See more keywords
In Vitro, In Silico and Ex Vivo Studies of Dihydroartemisinin Derivatives as Antitubercular Agents.
Sign Up to like & getrecommendations! Published in 2019 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026619666190305131425
Abstract: INTRODUCTION As a part of our drug discovery program for anti-tubercular agents, dihydroartemisinin (DHA-1) was screened against Mtb H37Rv, which showed moderate anti-tubercular activity (>25.0 µg/mL). These results prompted us to carry out the chemical… read more here.
Keywords: silico vivo; vitro silico; dha; vivo studies ... See more keywords
In Silico and In Vivo Evaluation of microRNA-181c-5p’s Role in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13122343
Abstract: Hepatocellular carcinoma (HCC) is a fatal disease, accounting for 75–85% of primary liver cancers. The conclusive research on miR-181c-5p’s role in hepatocarcinogenesis, whether it has oncogenic effects or acts as a tumor repressor, is limited… read more here.
Keywords: hepatocellular carcinoma; hcc; mir 181c; silico vivo ... See more keywords
Peptide Mapping, In Silico and In Vivo Analysis of Allergenic Sorghum Profilin Peptides
Sign Up to like & getrecommendations! Published in 2019 at "Medicina"
DOI: 10.3390/medicina55050178
Abstract: Background and objectives: Nearly 20–30% of the world’s population suffers from allergic rhinitis, among them 15% are progressing to asthma conditions. Sorghum bicolor profilin (Sorb PF), one of the panallergens, was identified, but the allergen… read more here.
Keywords: silico vivo; profilin; mapping silico; sorghum profilin ... See more keywords
UPLC-LTQ-Orbitrap-Based Cell Metabolomics and Network Pharmacology Analysis to Reveal the Potential Antiarthritic Effects of Pristimerin: In Vitro, In Silico and In Vivo Study
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12090839
Abstract: Rheumatoid arthritis (RA) is characterized by systemic inflammation and synovial hyperplasia. Pristimerin, a natural triterpenoid isolated from plants belonging to the Celastraceae and Hippocrateaceae families, has been reported to exhibit anti-inflammation and anti-proliferation activities. Our… read more here.
Keywords: pharmacology; vitro silico; study; silico vivo ... See more keywords
Analysis of Antidiabetic Activity of Squalene via In Silico and In Vivo Assay
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28093783
Abstract: Squalene has been tested widely in pharmacological activity including anticancer, antiinflammatory, antioxidant, and antidiabetic properties. This study aims to examine antidiabetic activity of squalene in silico and in vivo models. In the in silico model,… read more here.
Keywords: analysis; activity; silico vivo; squalene ... See more keywords
In Silico and In Vivo Studies of a Tumor-Penetrating and Interfering Peptide with Antitumoral Effect on Xenograft Models of Breast Cancer
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15041180
Abstract: The combination of a tumor-penetrating peptide (TPP) with a peptide able to interfere with a given protein–protein interaction (IP) is a promising strategy with potential clinical application. Little is known about the impact of fusing… read more here.
Keywords: effect; breast cancer; tpp; silico vivo ... See more keywords
Phytoecdysteroids and Anabolic Effect of Atriplex dimorphostegia: UPLC-PDA-MS/MS Profiling, In Silico and In Vivo Models
Sign Up to like & getrecommendations! Published in 2023 at "Plants"
DOI: 10.3390/plants12010206
Abstract: Atriplex dimorphostegia (Saltbush) is an annual halophytic shrub that is widely distributed across various parts of Asia. The current study is the first to report the metabolites profile of the total ethanol extract of the… read more here.
Keywords: uplc pda; tead; silico vivo; anabolic effect ... See more keywords