Integrated in silico and in vivo approaches to investigate effects of BDE-99 mediated by the nuclear receptors on developing zebrafish.
Sign Up to like & getrecommendations! Published in 2018 at "Environmental toxicology and chemistry"
DOI: 10.1002/etc.4000
Abstract: One of the most abundant polybrominated diphenyl ethers (PBDEs) is 2,2',4,4',5-pentabromodiphenyl ether (BDE-99), which persists and potentially bioaccumulates in aquatic wildlife. Previous studies in mammals have shown that BDE-99 affects development and disrupts certain endocrine… read more here.
Keywords: nuclear receptors; silico vivo; receptor; mediated nuclear ... See more keywords
Pentachlorophenol affected both reproductive and interrenal systems: In silico and in vivo evidence.
Sign Up to like & getrecommendations! Published in 2017 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2016.09.099
Abstract: The present study investigated the effects on reproductive and interrenal system by pentachlorophenol (PCP) using in silico and in vivo assays. Molecular docking results indicated interacting potency of PCP with steroid receptors (ERα, ERβ, AR, GR)… read more here.
Keywords: silico vivo; reproductive interrenal; evidence; pcp ... See more keywords
In Silico and In Vivo Investigation of the Anti-Hyperglycemic Effects of Caffeic Acid
Sign Up to like & getrecommendations! Published in 2025 at "ACS Omega"
DOI: 10.1021/acsomega.4c11062
Abstract: Hyperglycemia, characterized by elevated blood glucose levels, is a major risk factor for diabetes mellitus and its complications. While conventional therapies are effective, they are often associated with side effects and high costs, necessitating alternative… read more here.
Keywords: vivo; silico vivo; investigation anti; caffeic acid ... See more keywords
Aromatase inhibitors identified from Saraca asoca to treat infertility in women with polycystic ovary syndrome via in silico and in vivo studies
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2024.2310793
Abstract: Abstract Polycystic ovary syndrome (PCOS) is a widely occurring metabolic disorder causing infertility in 70%–80% of the affected women. Saraca asoca, an ancient medicinal herb, has been shown to have therapeutic effects against infertility and… read more here.
Keywords: infertility; polycystic ovary; ovary syndrome; silico vivo ... See more keywords
In silico and in␣vivo analyses reveal key metabolic pathways enabling the fermentative utilization of glycerol in Escherichia coli.
Sign Up to like & getrecommendations! Published in 2021 at "Microbial biotechnology"
DOI: 10.1111/1751-7915.13938
Abstract: Most microorganisms can metabolize glycerol when external electron acceptors are available (i.e. under respiratory conditions). However, few can do so under fermentative conditions owing to the unique redox constraints imposed by the high degree of… read more here.
Keywords: escherichia coli; glycerol escherichia; silico vivo; glycerol ... See more keywords
Evaluation of Antiurolithiatic Effects of Moringa oleifera Lam. Leaves Extract: In-vitro, in-silico and in-vivo Approaches
Sign Up to like & getrecommendations! Published in 2024 at "Dose-Response"
DOI: 10.1177/15593258241301222
Abstract: Objective: Moringa oleifera Lam. (Moringaceae), has traditionally been used for various renal diseases including urolithiasis. Considering the therapeutic and nutritional values, the present study was designed to investigate the antiurolithiatic potential of M. oleifera leaves… read more here.
Keywords: vitro silico; oleifera; vivo; silico vivo ... See more keywords
In Silico and In Vivo Hepatorenal Protective Effect of Chitosan-Loaded Chrysin Nanoparticles in Obese Rats.
Sign Up to like & getrecommendations! Published in 2025 at "Current topics in medicinal chemistry"
DOI: 10.2174/0115680266388484250807033921
Abstract: INTRODUCTION Obesity, a widespread health condition marked by excessive body fat, markedly elevates the risk of chronic diseases and has emerged as a major global health issue. Chrysin, a flavonoid with promising health benefits, exhibits… read more here.
Keywords: chrysin nanoparticles; orally hfd; obesity; silico vivo ... See more keywords
In Vitro, In Silico and Ex Vivo Studies of Dihydroartemisinin Derivatives as Antitubercular Agents.
Sign Up to like & getrecommendations! Published in 2019 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026619666190305131425
Abstract: INTRODUCTION As a part of our drug discovery program for anti-tubercular agents, dihydroartemisinin (DHA-1) was screened against Mtb H37Rv, which showed moderate anti-tubercular activity (>25.0 µg/mL). These results prompted us to carry out the chemical… read more here.
Keywords: silico vivo; vitro silico; dha; vivo studies ... See more keywords
In Silico and In Vivo Evaluation of microRNA-181c-5p’s Role in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13122343
Abstract: Hepatocellular carcinoma (HCC) is a fatal disease, accounting for 75–85% of primary liver cancers. The conclusive research on miR-181c-5p’s role in hepatocarcinogenesis, whether it has oncogenic effects or acts as a tumor repressor, is limited… read more here.
Keywords: hepatocellular carcinoma; hcc; mir 181c; silico vivo ... See more keywords
A Holistic In Silico and In Vivo Approach to Exploring the Antidiabetic, Antioxidant, and Hepatoprotective Properties of Rose of Sharon
Sign Up to like & getrecommendations! Published in 2024 at "Life"
DOI: 10.3390/life14060686
Abstract: Diabetes mellitus (DM) is a significant global health burden that necessitates the exploration of effective and accessible therapeutic options. Phytotherapy has played a vital role in healthcare, with plant extracts being integral to traditional medicinal… read more here.
Keywords: approach exploring; rose sharon; silico vivo; vivo approach ... See more keywords
Peptide Mapping, In Silico and In Vivo Analysis of Allergenic Sorghum Profilin Peptides
Sign Up to like & getrecommendations! Published in 2019 at "Medicina"
DOI: 10.3390/medicina55050178
Abstract: Background and objectives: Nearly 20–30% of the world’s population suffers from allergic rhinitis, among them 15% are progressing to asthma conditions. Sorghum bicolor profilin (Sorb PF), one of the panallergens, was identified, but the allergen… read more here.
Keywords: silico vivo; profilin; mapping silico; sorghum profilin ... See more keywords