XAV‐939 inhibits epithelial‐mesenchymal transformation in pulmonary fibrosis induced by crystalline silica via the Wnt signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23693
Abstract: Silicosis is an occupational lung disease that results from long‐term inhalation of free silica dust, the expression is sustained inflammation response, fibroblast hyperplasia, and excessive collagen deposit, bringing about pulmonary interstitial fibrosis. Wnt signaling pathway… read more here.
Keywords: signaling pathway; silicosis; wnt signaling; fibrosis ... See more keywords
EBUS-TBNA is Sufficient for Successful Diagnosis of Silicosis with Mediastinal Lymphadenopathy
Sign Up to like & getrecommendations! Published in 2018 at "Lung"
DOI: 10.1007/s00408-018-0129-3
Abstract: BackgroundSilicosis is an occupational lung disease resulting from inhalation of respirable crystalline silica. Recently, an international silicosis epidemic has been noted among artificial stone workers.ObjectiveEndobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is currently used for patients… read more here.
Keywords: diagnosis; mediastinal lymphadenopathy; ebus tbna; silicosis ... See more keywords
Label-free Raman spectroscopy characterizes signatures of inflammation and fibrosis in the silicosis.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2022.03.107
Abstract: Silicosis is an occupational disease that seriously damages the life and health of miners. Herein, we constructed a mouse model of silicosis and used label-free confocal Raman spectroscopy to analyze the biomolecular variations in lung… read more here.
Keywords: raman spectroscopy; label free; silicosis; spectroscopy ... See more keywords
Peripheral blood circular RNA hsa_circ_0058493 as a potential novel biomarker for silicosis and idiopathic pulmonary fibrosis.
Sign Up to like & getrecommendations! Published in 2022 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2022.113451
Abstract: Existing studies reported that some circular RNAs (circRNAs) play vital roles in the development of pulmonary fibrosis. However, few studies explored the biomarker potential of circRNAs for pulmonary fibrosis based on population data. Therefore, we… read more here.
Keywords: silicosis; biomarker; pulmonary fibrosis; circ 0058493 ... See more keywords
Nicotine induces apoptosis through exacerbation of blocked alveolar macrophage autophagic degradation in silicosis.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2020.09.019
Abstract: Silica dust mainly attacks alveolar macrophages (AMs). The apoptosis of AMs is correlated with the progress of silicosis. Our previous study showed that autophagic degradation was blocked in AMs from silicosis patients. However, the effects… read more here.
Keywords: apoptosis; nicotine induces; autophagic degradation; silicosis ... See more keywords
Renal involvement in a silicosis patient – case report and literature review
Sign Up to like & getrecommendations! Published in 2019 at "Renal Failure"
DOI: 10.1080/0886022x.2019.1696209
Abstract: Abstract A 43-year-old Chinese man with a silicosis history was admitted to our hospital due to bilateral lower extremity edema for 1 year, exacerbating with hematuria for 2 months. He started working as a coal miner 30 years… read more here.
Keywords: silicosis; involvement silicosis; silicosis patient; patient case ... See more keywords
Identification of key pathways and genes in the progression of silicosis based on WGCNA
Sign Up to like & getrecommendations! Published in 2022 at "Inhalation Toxicology"
DOI: 10.1080/08958378.2022.2102700
Abstract: Abstract Silicosis, induced by inhaling silica particles in workplaces, is one of the most common occupational diseases. The prognosis of silicosis and its consequent fibrosis is extremely poor due to limited treatment modalities and lack… read more here.
Keywords: identification key; silicosis; pathways genes; silicosis fibrosis ... See more keywords
Engineering solutions to breath tests based on an e-nose system for silicosis screening and early detection in miners.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of breath research"
DOI: 10.1088/1752-7163/ac5f13
Abstract: OBJECTIVES This study aims to develop an engineering solution to breath tests using an electronic nose (e-nose), and evaluate its diagnosis accuracy for silicosis. Influencing factors of this technique were explored. METHODS 398 non-silicosis miners… read more here.
Keywords: breath tests; screening early; silicosis; breath ... See more keywords
A Novel Variant of Desmoplakin Is Potentially Associated with Silicosis Risk.
Sign Up to like & getrecommendations! Published in 2018 at "DNA and cell biology"
DOI: 10.1089/dna.2018.4370
Abstract: Two genome-wide association studies and one sequencing study have coincidently reported significant associations of single nucleotide polymorphisms (SNPs) in the desmoplakin (DSP) gene with the risk of pulmonary fibrosis (mainly idiopathic pulmonary fibrosis). However, these… read more here.
Keywords: risk; silicosis risk; silicosis; pulmonary fibrosis ... See more keywords
Kaempferol Modulates Autophagy and Alleviates Silica-Induced Pulmonary Fibrosis.
Sign Up to like & getrecommendations! Published in 2019 at "DNA and cell biology"
DOI: 10.1089/dna.2019.4941
Abstract: Silicosis is an occupational disease characterized as inflammatory cells infiltration and severe progressive pulmonary fibrosis. Kaempferol (Kae), a flavonoid exists in many plants and fruits, has been proved to have anti-inflammatory and antifibrosis functions. However,… read more here.
Keywords: silicosis; induced pulmonary; silica induced; pulmonary fibrosis ... See more keywords
Adenoviral Transduction of Dickkopf-1 Alleviates Silica-induced Silicosis Development in Lungs of Mice.
Sign Up to like & getrecommendations! Published in 2021 at "Human gene therapy"
DOI: 10.1089/hum.2021.008
Abstract: Silicosis is an occupational disease caused by inhalation of silica dust, which is hallmarked by progressive pulmonary fibrosis associated with poor prognosis. Wnt/β-catenin signaling is implicated in the development of fibrosis and is a therapeutic… read more here.
Keywords: wnt catenin; silicosis; silica induced; transduction ... See more keywords