Possible protective role of silybin against polymyxin E‐induced toxic effect in rat kidneys: A biochemical approach
Sign Up to like & getrecommendations! Published in 2017 at "Neurourology and Urodynamics"
DOI: 10.1002/nau.23249
Abstract: Polymyxin E was used for treating gram‐negative bacterial infections but not recently for fear of its nephrotoxicity. Silybin has potential to counteract nephrotoxicity; however, few studies have investigated its protective effect on the kidney in… read more here.
Keywords: effect; protective role; polymyxin; possible protective ... See more keywords
Phytochemicals protect L02 cells against hepatotoxicity induced by emodin via the Nrf2 signaling pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology research"
DOI: 10.1039/c9tx00220k
Abstract: Dihydromyricetin (DMY), hyperoside and silybin are phytochemicals that belong to a class called flavonoids, and they have been used in liver protection pharmaceutical preparations, but the specific mechanism of these chemicals is still unclarified. This… read more here.
Keywords: hyperoside silybin; dmy hyperoside; hepatotoxicity; silybin ... See more keywords
Silybin enhances the blood concentration of brexpiprazole in rats by downregulating expression of CYP3A4 and CYP2D6.
Sign Up to like & getrecommendations! Published in 2020 at "Die Pharmazie"
DOI: 10.1691/ph.2020.9935
Abstract: In this study, we investigated the effect of silybin on the pharmacokinetics of brexpiprazole and the underlying mechanism in rats. Two groups of animals received silybin at different doses (50 mg/kg, 25 mg/kg) for 2… read more here.
Keywords: concentration brexpiprazole; blood concentration; cyp3a4 cyp2d6; brexpiprazole ... See more keywords
Co-delivery doxorubicin and silybin for anti-hepatoma via enhanced oral hepatic-targeted efficiency
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s187888
Abstract: Background To establish the combination of doxorubicin (DOX) and silybin (SLB) in oral hepatic-targeting liposomes with the goal of reducing cardiotoxic side effects and improve oral hepatoma treatment. Methods Distearoylphosphatidylethanolamine–polyethylene glycol–cholic acid-modified liposomes (CA-LP) were… read more here.
Keywords: dox slb; hepatoma; silybin; oral hepatic ... See more keywords
PANC-1 cancer stem-like cell death with silybin encapsulated in polymersomes and deregulation of stemness-related miRNAs and their potential targets
Sign Up to like & getrecommendations! Published in 2021 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2021.54001.12136
Abstract: Objective(s): Cancer stem cells (CSCs) have powerful self-renewal ability and tumor recurrence. Pancreatic ductal adenocarcinoma is a malignancy with high mortality rate and ˃5% survival. Silybin has anticancer and hepatoprotective properties. We loaded silybin in… read more here.
Keywords: cancer stem; potential targets; expression; cancer ... See more keywords
Activation of Sirtuin 3 by Silybin Attenuates Mitochondrial Dysfunction in Cisplatin-induced Acute Kidney Injury
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2017.00178
Abstract: Silybin is a secondary metabolite isolated from the seeds of blessed milk thistle (Silybum marianum) that has anti-inflammatory, antioxidative, antifibrotic, and antitumor properties. Here, we showed that silybin protected against cisplatin-induced acute kidney injury (AKI)… read more here.
Keywords: kidney injury; cisplatin; acute kidney; cisplatin induced ... See more keywords
Silybin Showed Higher Cytotoxic, Antiproliferative, and Anti-Inflammatory Activities in the CaCo Cancer Cell Line while Retaining Viability and Proliferation in Normal Intestinal IPEC-1 Cells
Sign Up to like & getrecommendations! Published in 2023 at "Life"
DOI: 10.3390/life13020492
Abstract: The anticancer potential of silymarin is well known, including its anti-inflammatory as well as antiproliferative effect mediated by influencing the cell cycle, suppression of apoptosis, and inhibition of cell-survival kinases. However, less is known about… read more here.
Keywords: cell; effect; silybin; anti inflammatory ... See more keywords
Excess fructose and fatty acids trigger a model of non‑alcoholic fatty liver disease progression in vitro: Protective effect of the flavonoid silybin.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of molecular medicine"
DOI: 10.3892/ijmm.2019.4234
Abstract: Overconsumption of fats and sugars is a major cause of development of non‑alcoholic fatty liver disease (NAFLD). The main objectives of the present study were to explore the pathways sustaining the interfering metabolic effects of… read more here.
Keywords: alcoholic fatty; non alcoholic; fructose fatty; progression ... See more keywords
Quantitative estimation of Silybin in Iraqi Silybum marianum by HPLC
Sign Up to like & getrecommendations! Published in 2021 at "Research Journal of Pharmacy and Technology"
DOI: 10.52711/0974-360x.2021.00794
Abstract: Milk thistle's extract by an organic solvent is known as silymarin, which is a mixture of about 75% flavolignan and trace content of flavonoid (mainly taxifolin), other ingredients involve fatty acids and polyphenolic compounds. The… read more here.
Keywords: estimation silybin; quantitative estimation; silybum marianum; iraqi silybum ... See more keywords