Synthesis of β-Silyl α-Amino Acids via Visible-Light-Mediated Hydrosilylation.
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DOI: 10.1021/acs.orglett.1c00065
Abstract: An expedient synthesis of β-silyl α-amino acids is reported via the application of visible-light-mediated hydrosilylation. The reaction utilizes readily accessible and structurally diverse hydrosilanes to provide radicals for conjugate addition to dehydroalanine ester and analogues.… read more here.
Keywords: amino acids; silyl amino; mediated hydrosilylation; light mediated ... See more keywords
Synthesis of β-Silyl-α-amino Acid Derivatives by Cu-Catalyzed Regio- and Enantioselective Silylamination of α,β-Unsaturated Esters.
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DOI: 10.1021/acs.orglett.2c00309
Abstract: A copper-catalyzed silylamination of α,β-unsaturated esters with silylboranes and hydroxylamines has been developed to afford the corresponding β-silyl-α-amino acid derivatives, which are of great interest in medicinal and pharmaceutical chemistry. Additionally, by using a suitable… read more here.
Keywords: acid derivatives; silyl amino; silylamination unsaturated; amino acid ... See more keywords