DMSO-Promoted Difluoroalkylation of Organophosphonium Salts with Difluoroenol Silyl Ethers.
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DOI: 10.1021/acs.orglett.2c02088
Abstract: An efficient method for the synthesis of β,β-di(hetero)aryl-α,α-difluorinated ketones using readily available organophosphonium salts and difluoroenol silyl ethers has been developed. This mild reaction features a good functional group tolerance, a scaled-up synthesis, and synthetic… read more here.
Keywords: salts difluoroenol; difluoroenol silyl; silyl ethers; organophosphonium salts ... See more keywords
Catalytic Enantioselective Amination of Enol Silyl Ethers Using a Chiral Paddle-Wheel Diruthenium Complex.
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DOI: 10.1021/acs.orglett.3c00940
Abstract: A chiral paddle-wheel dinuclear ruthenium catalyst was applied to a catalytic asymmetric nitrene-transfer reaction with enol silyl ethers. The ruthenium catalyst was applicable to aliphatic enol silyl ethers as well as aryl-containing enol silyl ethers.… read more here.
Keywords: chiral paddle; paddle wheel; enol silyl; silyl ethers ... See more keywords
Organocatalytic Asymmetric Synthesis of Si-Stereogenic Silyl Ethers
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DOI: 10.1021/jacs.2c04261
Abstract: Functionalized enantiopure organosilanes are important building blocks with applications in various fields of chemistry; nevertheless, asymmetric synthetic methods for their preparation are rare. Here we report the first organocatalytic enantioselective synthesis of tertiary silyl ethers… read more here.
Keywords: silyl ethers; synthesis stereogenic; organocatalytic asymmetric; asymmetric synthesis ... See more keywords
Leveraging Regio- and Stereoselective C(sp3)-H Functionalization of Silyl Ethers to Train a Logistic Regression Classification Model for Predicting Site-Selectivity Bias.
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DOI: 10.1021/jacs.2c04383
Abstract: The C-H functionalization of silyl ethers via carbene-induced C-H insertion represents an efficient synthetic disconnection strategy. In this work, site- and stereoselective C(sp3)-H functionalization at α, γ, δ, and even more distal positions to the… read more here.
Keywords: silyl ethers; functionalization; functionalization silyl; model ... See more keywords
Rh(III)-catalyzed redox-neutral C-H alkenylation of benzamides with gem-difluorohomoallylic silyl ethers via β-H elimination.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc00529a
Abstract: Fluorinated molecules are widely used in pharmaceutical and agrochemical industries. Herein we report the synthesis of 2-(3,3-difluoro-4-(silyloxy)but-1-en-1-yl)benzamides from the unprecedented rhodium(III)-catalyzed alkenylation of various benzamides with difluorohomoallylic silyl ethers. The practicability of this protocol is… read more here.
Keywords: silyl ethers; alkenylation; difluorohomoallylic silyl; redox neutral ... See more keywords