Practical synthesis of silyl-protected and functionalized propargylamines using nanostructured Ag/TiO2 and Pt/TiO2 as active recyclable catalysts
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DOI: 10.1007/s11696-018-0604-6
Abstract: Herein we report the use of Ag/TiO2 and Pt/TiO2 nanocatalysts to promote the synthesis of a series of silyl-protected and functionalized propargylamine derivatives through alkyne–amine–aldehyde (A3) coupling under microwave condition using water as solvent in… read more here.
Keywords: tio2; tio2 tio2; protected functionalized; silyl protected ... See more keywords
Silyl-protected propargyl glycine for multiple labeling of peptides by chemoselective silyl-deprotection
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DOI: 10.1016/j.tetlet.2021.153093
Abstract: Abstract We synthesized Fmoc-propargyl glycine derivatives bearing different silyl protecting groups that can be readily introduced by using a standard solid-phase peptide coupling procedures. Taking advantage of the orthogonality between the different silyl protecting groups,… read more here.
Keywords: protected propargyl; silyl; propargyl glycine; silyl protected ... See more keywords
Tuning the Chemoselectivity of Silyl Protected Rhamnals by Temperature and Brønsted Acidity: Kinetically Controlled 1,2-Addition vs Thermodynamically Controlled Ferrier Rearrangement.
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DOI: 10.1021/acs.orglett.9b00009
Abstract: An acidity- and temperature-dependent chemoselective glycosylation of silyl-protected rhamnals with alcohols has been revealed. The reaction undergoes a 1,2-addition pathway with (±)-CSA as the catalyst at rt, affording kinetically controlled 2-deoxyl rhamnosides. In contrast, only… read more here.
Keywords: ferrier rearrangement; temperature; silyl protected; thermodynamically controlled ... See more keywords