Synthesis of β-Silyl-α-amino Acid Derivatives by Cu-Catalyzed Regio- and Enantioselective Silylamination of α,β-Unsaturated Esters.
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DOI: 10.1021/acs.orglett.2c00309
Abstract: A copper-catalyzed silylamination of α,β-unsaturated esters with silylboranes and hydroxylamines has been developed to afford the corresponding β-silyl-α-amino acid derivatives, which are of great interest in medicinal and pharmaceutical chemistry. Additionally, by using a suitable… read more here.
Keywords: acid derivatives; silyl amino; silylamination unsaturated; amino acid ... See more keywords