Effect of Silymarin Treatment on Circulating Bilirubin and Cardiovascular Disease Risk Factors in Healthy Men: A Single‐Blind, Randomized Crossover Trial
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.962
Abstract: This clinical trial (ACTRN12619001296123) investigated the impact of silymarin (Legalon®) on circulating bilirubin concentration, lipid status, systemic inflammation, and antioxidant status. The study design was a randomized, placebo‐controlled, single‐blind crossover trial of healthy men (18‐65… read more here.
Keywords: trial; silymarin; crossover; silymarin treatment ... See more keywords
Potential role of potassium and chloride channels in regulation of silymarin‐induced apoptosis in Candida albicans
Sign Up to like & getrecommendations! Published in 2018 at "IUBMB Life"
DOI: 10.1002/iub.1716
Abstract: Silymarin, which is derived from the seeds of Silybum marianum, has been widely used to prevent and treat liver diseases. In our previous study, we reported that at concentrations above the minimal inhibitory concentration (MIC),… read more here.
Keywords: potassium; silymarin; concentration mic; candida albicans ... See more keywords
Lifestyle and silymarin: a fight against liver damage in NAFLD associated - prediabetic disease
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Diabetes and Metabolic Disorders"
DOI: 10.1007/s40200-020-00576-3
Abstract: Background Nonalcoholic fatty liver disease (NAFLD) is common in both prediabetic patients and healthy overweight individuals, yet it remains understudied. This study investigates the effects of hepatic steatosis on fibrosis and evaluates the major predictors… read more here.
Keywords: silymarin; study; prediabetic patients; significant fibrosis ... See more keywords
System biology-based investigation of Silymarin to trace hepatoprotective effect
Sign Up to like & getrecommendations! Published in 2022 at "Computers in biology and medicine"
DOI: 10.1016/j.compbiomed.2022.105223
Abstract: Silymarin is used as a hepatoprotective agent since ancient times which could be via its potent anti-oxidant effect. However, the mode of silymarin for the hepatoprotective effect has not been established with the targets involved… read more here.
Keywords: silymarin; hepatoprotective effect; system biology; biology ... See more keywords
The impact of silymarin on antioxidant and oxidative status in patients with β-thalassemia major: A crossover, randomized controlled trial.
Sign Up to like & getrecommendations! Published in 2017 at "Complementary therapies in medicine"
DOI: 10.1016/j.ctim.2017.08.007
Abstract: BACKGROUND & AIMS Blood transfusion therapy is lifesaving for individuals with β-thalassemia major (β-TM). Iron burden following blood transfusion is the main cause of oxidative stress (OS) and organ dysfunction in these patients. The aim… read more here.
Keywords: oxidative status; silymarin; thalassemia major; antioxidant oxidative ... See more keywords
Formulation and biopharmaceutical evaluation of supersaturatable self‐nanoemulsifying drug delivery systems containing silymarin
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.11.036
Abstract: Graphical abstract Figure. No caption available. Abstract The first objective of this study was to optimize a supersaturatable self‐nanoemulsifying drug delivery system (S‐SNEDDS) containing silymarin through the investigation of the single and synergistic effect of… read more here.
Keywords: silymarin; nanoemulsifying drug; drug delivery; containing silymarin ... See more keywords
Formulation and optimization of lyophilized nanosuspension tablets to improve the physicochemical properties and provide immediate release of silymarin
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.03.064
Abstract: Graphical abstract Figure. No caption available. ABSTRACT Silymarin (SLM) is a hepatoprotective herbal drug characterized by low aqueous solubility and, consequently, low oral bioavailability. The objective of this study was to enhance the physiochemical properties… read more here.
Keywords: silymarin; microscopy; optimization lyophilized; lyophilized nanosuspension ... See more keywords
Silymarin impacts on immune system as an immunomodulator: One key for many locks
Sign Up to like & getrecommendations! Published in 2017 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2017.06.030
Abstract: Abstract Silymarin is a flavonoid complex extracted from the Silybum marianum plant. It acts as a strong antioxidant and free radical scavenger by different mechanisms. But in addition to antioxidant effects, silymarin/silybin reveals immunomodulatory affects… read more here.
Keywords: impacts immune; silymarin; immunomodulator; effects silymarin ... See more keywords
Design and optimization of silymarin loaded in lyophilized fast melt tablets to attenuate lung toxicity induced via HgCl2 in rats
Sign Up to like & getrecommendations! Published in 2022 at "Drug Delivery"
DOI: 10.1080/10717544.2022.2068696
Abstract: Abstract The present study aimed to develop fast melting tablets (FMTs) using silymarin (SM) owing to FMTs rapid disintegration and dissolution. FMTs represent a pathway to help patients to increase their compliance level of treatment… read more here.
Keywords: optimization; silymarin; lung toxicity; lung ... See more keywords
Silymarin inhibits the lipogenic pathway and reduces worsening of non-alcoholic fatty liver disease (NAFLD) in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Archives of physiology and biochemistry"
DOI: 10.1080/13813455.2022.2138445
Abstract: CONTEXT The role of silymarin in hepatic lipid dysfunction and its possible mechanisms of action were investigated. OBJECTIVE To evaluate the effects of silymarin on hepatic and metabolic profiles in mice fed with 30% fructose… read more here.
Keywords: silymarin; silymarin inhibits; reduces worsening; lipogenic pathway ... See more keywords
Silymarin Prevents High-Fat Diet-Induced Muscle Atrophy by Regulating Protein Degradation and Synthesis in Mice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal food"
DOI: 10.1089/jmf.2021.k.0175
Abstract: Silymarin is found in Silybum marianum. We investigated the effect of silymarin on muscle atrophy in obese mice. The experimental mice were divided into three groups: CON, normal diet; HFD, 60% high-fat diet (HF); and… read more here.
Keywords: silymarin; group; muscle atrophy; high fat ... See more keywords