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Published in 2019 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-019-01431-8
Abstract: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exacerbates mitochondrial impairment and α-synuclein expression leading to Parkinsonism. Impaired mitochondria and over-expressed α-synuclein are degraded and eliminated via macroautophagy and chaperone-mediated autophagy. Owing to multiple properties, silymarin protects from oxidative stress–mediated cellular…
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Keywords:
mptp induced;
methyl phenyl;
parkinsonism;
phenyl tetrahydropyridine ... See more keywords