Patient Similarity Networks for Precision Medicine.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2018.05.037
Abstract: Clinical research and practice in the 21st century is poised to be transformed by analysis of computable electronic medical records and population-level genome-scale patient profiles. Genomic data capture genetic and environmental state, providing information on… read more here.
Keywords: medicine; patient similarity; precision medicine; similarity networks ... See more keywords
Revealing Unexplored Sequence-Function Space Using Sequence Similarity Networks.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00473
Abstract: The rapidly expanding number of protein sequences found in public databases can improve our understanding of how protein functions evolve. However, our current knowledge of protein function likely represents a small fraction of the diverse… read more here.
Keywords: protein; similarity networks; sequence similarity; unexplored sequence ... See more keywords
AMHMDA: attention aware multi-view similarity networks and hypergraph learning for miRNA-disease associations identification
Sign Up to like & getrecommendations! Published in 2023 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbad094
Abstract: In recent years, many experiments have proved that microRNAs (miRNAs) play a variety of important regulatory roles in cells, and their abnormal expression can lead to the emergence of specific diseases. Therefore, it is greatly… read more here.
Keywords: disease; similarity networks; disease associations; attention ... See more keywords
Gene Similarity Networks Unveil a Potential Novel Unicellular Group Closely Related to Animals from the Tara Oceans Expedition
Sign Up to like & getrecommendations! Published in 2020 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evaa117
Abstract: Abstract The Holozoa clade comprises animals and several unicellular lineages (choanoflagellates, filastereans, and teretosporeans). Understanding their full diversity is essential to address the origins of animals and other evolutionary questions. However, they are poorly known.… read more here.
Keywords: diversity; oceans expedition; similarity networks; tara oceans ... See more keywords
Comparative Genomics and Metabolomics in the Genus Nocardia
Sign Up to like & getrecommendations! Published in 2020 at "mSystems"
DOI: 10.1128/msystems.00125-20
Abstract: Our work emphasizes that Nocardia represent a prolific source for natural products rivaling better-characterized genera such as Streptomyces or Amycolatopsis. Furthermore, we showed that large-scale analysis of biosynthetic gene clusters using similarity networks with high… read more here.
Keywords: biosynthetic gene; similarity networks; gene; gene clusters ... See more keywords
Fusing multiple protein-protein similarity networks to effectively predict lncRNA-protein interactions
Sign Up to like & getrecommendations! Published in 2017 at "BMC Bioinformatics"
DOI: 10.1186/s12859-017-1819-1
Abstract: BackgroundLong non-coding RNA (lncRNA) plays important roles in many biological and pathological processes, including transcriptional regulation and gene regulation. As lncRNA interacts with multiple proteins, predicting lncRNA-protein interactions (lncRPIs) is an important way to study… read more here.
Keywords: protein; protein interactions; similarity networks; multiple protein ... See more keywords