Simple Enantioselective Syntheses of (2R,6R)-Hydroxynorketamine and Related Potential Rapid-Onset Antidepressants.
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DOI: 10.1021/acs.orglett.7b02498
Abstract: A novel strategy for accessing cyclic α-amino ketones enantioselectively has opened a simple synthetic route to the antidepressant (2R,6R)-hydroxynorketamine and numerous analogues. Mechanistically guided catalyst selection was essential in an initial olefin epoxidation step. In… read more here.
Keywords: potential rapid; hydroxynorketamine related; enantioselective syntheses; simple enantioselective ... See more keywords