Molecular Dynamics Simulations Reveal Structural Interconnections within Sec14-PH Bipartite Domain from Human Neurofibromin
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DOI: 10.3390/ijms23105707
Abstract: Neurofibromin, the main RasGAP in the nervous system, is a 2818 aa protein with several poorly characterized functional domains. Mutations in the NF1-encoding gene lead to an autosomal dominant syndrome, neurofibromatosis, with an incidence of… read more here.
Keywords: dynamics simulations; reveal structural; molecular dynamics; simulations reveal ... See more keywords
Molecular Dynamic Simulations Reveal the Activation Mechanisms of Oxidation-Induced TRPV1
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DOI: 10.3390/ijms24119553
Abstract: Transient receptor potential vanilloid 1 (TRPV1), a non-selective cation channel, can be directly activated by oxidants through cysteine modification. However, the patterns of cysteine modification are unclear. Structural analysis showed that the free sulfhydryl groups… read more here.
Keywords: c387 c391; molecular dynamic; simulations reveal; dynamic simulations ... See more keywords