Molecular Dynamics Simulations Reveal Octanoylated Hyaluronic Acid Enhances Liposome Stability, Stealth and Targeting
Sign Up to like & getrecommendations! Published in 2024 at "ACS Omega"
DOI: 10.1021/acsomega.4c03526
Abstract: Liposome-based drug delivery systems have been widely used in drug and gene delivery. However, issues such as instability, immune clearance, and poor targeting have significantly limited their clinical utility. Consequently, there is an urgent need… read more here.
Keywords: stability; dynamics simulations; hyaluronic acid; molecular dynamics ... See more keywords
Predictive musculoskeletal simulations reveal the mechanistic link between speed, posture and energetics among extant mammals
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-52924-z
Abstract: An unusual pattern among the scaling laws in nature is that the fastest animals are neither the largest, nor the smallest, but rather intermediately sized. Because of the enormous diversity in animal shape, the mechanisms… read more here.
Keywords: musculoskeletal simulations; reveal mechanistic; size; speed ... See more keywords
Molecular Dynamics Simulations Reveal Structural Interconnections within Sec14-PH Bipartite Domain from Human Neurofibromin
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105707
Abstract: Neurofibromin, the main RasGAP in the nervous system, is a 2818 aa protein with several poorly characterized functional domains. Mutations in the NF1-encoding gene lead to an autosomal dominant syndrome, neurofibromatosis, with an incidence of… read more here.
Keywords: dynamics simulations; reveal structural; molecular dynamics; simulations reveal ... See more keywords
Molecular Dynamic Simulations Reveal the Activation Mechanisms of Oxidation-Induced TRPV1
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24119553
Abstract: Transient receptor potential vanilloid 1 (TRPV1), a non-selective cation channel, can be directly activated by oxidants through cysteine modification. However, the patterns of cysteine modification are unclear. Structural analysis showed that the free sulfhydryl groups… read more here.
Keywords: c387 c391; molecular dynamic; simulations reveal; dynamic simulations ... See more keywords