Simultaneous estimation of bi-directional causal effects and heritable confounding from GWAS summary statistics
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-26970-w
Abstract: Mendelian Randomisation (MR) is an increasingly popular approach that estimates the causal effect of risk factors on complex human traits. While it has seen several extensions that relax its basic assumptions, most suffer from two… read more here.
Keywords: simultaneous estimation; summary statistics; heritable confounder; causal effects ... See more keywords
A novel LC-MS/MS method for simultaneous estimation of acalabrutinib and its active metabolite acalabrutinib M27 in human plasma and application to a human pharmacokinetic study
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d1ra09026g
Abstract: A simple, specific, selective and accurate bioanalytical method was developed and validated for simultaneous estimation of acalabrutinib and its active metabolite in human plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Deuterated analogs of both the… read more here.
Keywords: human plasma; acalabrutinib active; estimation acalabrutinib; active metabolite ... See more keywords
Simultaneous estimation of parabens and bisphenol a in ready-to-eat foodstuffs by using QbD-driven high-pressure liquid chromatography method
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Environmental Analytical Chemistry"
DOI: 10.1080/03067319.2020.1756272
Abstract: Endocrine-disrupting chemicals (EDC) are harmful xenobiotics show casingv aried unwanted effects altering the endocrine system and its functions. Exposure of EDCs to humans occurs through route sin... read more here.
Keywords: ready eat; simultaneous estimation; eat foodstuffs; estimation parabens ... See more keywords
Development and validation of HPLC method for simultaneous estimation of erlotinib and niclosamide from liposomes optimized by screening design.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of liposome research"
DOI: 10.1080/08982104.2022.2162540
Abstract: The emerging drug resistance to the approved first-line drug therapy leads to clinical failure in cancer. Drug repurposing studies lead to the identification of many old drugs to be used for cancer treatment. Combining the… read more here.
Keywords: method; liposomes optimized; hplc method; simultaneous estimation ... See more keywords
Application of a Validated RP-HPLC Method in Solubility and Dissolution Testing for Simultaneous Estimation of Diacerein and Its Active Metabolite Rhein in Presence of Coformers in the Eutectic Tablet Formulation.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmaa109
Abstract: The present study aimed to develop and validate a novel reversed-phase high-performance liquid chromatography method for simultaneous estimation of Diacerein (DIA) and Rhein (Rh, alkaline degradation product and active metabolite) in the presence of various… read more here.
Keywords: active metabolite; presence; simultaneous estimation; method ... See more keywords
Development and Validation of Chemometrics-Assisted Green UPLC-MS/MS Bioanalytical Method for Simultaneous Estimation of Capecitabine and Lapatinib in Rat Plasma.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmab094
Abstract: A chemometrics-oriented green ultra-performance liquid chromatography-mass spectrometry/mass spectrometry method was developed and validated for the first-time simultaneous estimation of capecitabine (CAP) and lapatinib (LPB) along with imatinib (as internal standard (IS)) in rat plasma. Analytes… read more here.
Keywords: rat plasma; validation; simultaneous estimation; method ... See more keywords
Simultaneous Estimation of Neutron Flux and Reactivity in Nuclear Reactors
Sign Up to like & getrecommendations! Published in 2020 at "IEEE Transactions on Nuclear Science"
DOI: 10.1109/tns.2020.3005115
Abstract: In this article, we propose a methodology based on cubature Kalman filtering (CKF) for simultaneous estimation of two important variables of nuclear reactors, viz. the neutron flux and the total core reactivity, from signals of… read more here.
Keywords: simultaneous estimation; reactivity; neutron flux; estimation ... See more keywords
Non-invasive kinetic modelling of PET tracers with radiometabolites using a constrained simultaneous estimation method: evaluation with 11C-SB201745
Sign Up to like & getrecommendations! Published in 2018 at "EJNMMI Research"
DOI: 10.1186/s13550-018-0412-6
Abstract: BackgroundKinetic analysis of dynamic PET data requires an accurate knowledge of available PET tracer concentration within blood plasma over time, known as the arterial input function (AIF). The gold standard method used to measure the… read more here.
Keywords: image derived; simultaneous estimation; method; estimation method ... See more keywords
Simultaneous Estimation of Cinnamaldehyde and Eugenol in Essential Oils and Traditional and Ultrasound-Assisted Extracts of Different Species of Cinnamon Using a Sustainable/Green HPTLC Technique
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26072054
Abstract: A wide range of analytical techniques are reported for the determination of cinnamaldehyde (CCHO) and eugenol (EOH) in plant extracts and herbal formulations either alone or in combination. Nevertheless, sustainable/green analytical techniques for the estimation… read more here.
Keywords: technique; simultaneous estimation; ccho eoh; hptlc ... See more keywords
Simultaneous Estimation of Escitalopram and Clonazepam in Tablet Dosage Forms Using HPLC-DAD Method and Optimization of Chromatographic Conditions by Box-Behnken Design
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27134209
Abstract: The study aimed to develop a new reverse-phase high-performance liquid chromatography (RP-HPLC) method with diode array detection (DAD) detection for simultaneous estimation of escitalopram (EST) and clonazepam (CZP) in tablet dosage forms with a quality… read more here.
Keywords: tablet; design; simultaneous estimation; hplc method ... See more keywords
HPLC method for simultaneous estimation of paclitaxel and baicalein: pharmaceutical and pharmacokinetic applications.
Sign Up to like & getrecommendations! Published in 2022 at "Bioanalysis"
DOI: 10.4155/bio-2022-0100
Abstract: Aim: A novel HPLC method was developed and validated for the simultaneous estimation of paclitaxel (PTX) and baicalein (BAC). Materials & methods: The analytes were resolved in a C18 column using the aqueous solution of… read more here.
Keywords: estimation; estimation paclitaxel; hplc method; simultaneous estimation ... See more keywords