Simultaneous estimation of bi-directional causal effects and heritable confounding from GWAS summary statistics
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-26970-w
Abstract: Mendelian Randomisation (MR) is an increasingly popular approach that estimates the causal effect of risk factors on complex human traits. While it has seen several extensions that relax its basic assumptions, most suffer from two… read more here.
Keywords: simultaneous estimation; summary statistics; heritable confounder; causal effects ... See more keywords
Stability indicating RP-HPLC technique for simultaneous estimation of nirmatrelvir and ritonavir in their new copackaged dosage form for COVID-19 treatment
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-85776-8
Abstract: RP-HPLC technique was developed and optimized for simultaneous identification and estimation of nirmatrelvir (NIR) and ritonavir (RIT) in their new copackaged tablet. Stability of nirmatrelvir (NIR) was studied after exposure to different five stress conditions;… read more here.
Keywords: hplc technique; estimation; copackaged dosage; simultaneous estimation ... See more keywords
A novel LC-MS/MS method for simultaneous estimation of acalabrutinib and its active metabolite acalabrutinib M27 in human plasma and application to a human pharmacokinetic study
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d1ra09026g
Abstract: A simple, specific, selective and accurate bioanalytical method was developed and validated for simultaneous estimation of acalabrutinib and its active metabolite in human plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Deuterated analogs of both the… read more here.
Keywords: human plasma; acalabrutinib active; estimation acalabrutinib; active metabolite ... See more keywords
Simultaneous estimation of parabens and bisphenol a in ready-to-eat foodstuffs by using QbD-driven high-pressure liquid chromatography method
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Environmental Analytical Chemistry"
DOI: 10.1080/03067319.2020.1756272
Abstract: Endocrine-disrupting chemicals (EDC) are harmful xenobiotics show casingv aried unwanted effects altering the endocrine system and its functions. Exposure of EDCs to humans occurs through route sin... read more here.
Keywords: ready eat; simultaneous estimation; eat foodstuffs; estimation parabens ... See more keywords
Development and validation of HPLC method for simultaneous estimation of erlotinib and niclosamide from liposomes optimized by screening design.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of liposome research"
DOI: 10.1080/08982104.2022.2162540
Abstract: The emerging drug resistance to the approved first-line drug therapy leads to clinical failure in cancer. Drug repurposing studies lead to the identification of many old drugs to be used for cancer treatment. Combining the… read more here.
Keywords: method; liposomes optimized; hplc method; simultaneous estimation ... See more keywords
Application of a Validated RP-HPLC Method in Solubility and Dissolution Testing for Simultaneous Estimation of Diacerein and Its Active Metabolite Rhein in Presence of Coformers in the Eutectic Tablet Formulation.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmaa109
Abstract: The present study aimed to develop and validate a novel reversed-phase high-performance liquid chromatography method for simultaneous estimation of Diacerein (DIA) and Rhein (Rh, alkaline degradation product and active metabolite) in the presence of various… read more here.
Keywords: active metabolite; presence; simultaneous estimation; method ... See more keywords
Development and Validation of Chemometrics-Assisted Green UPLC-MS/MS Bioanalytical Method for Simultaneous Estimation of Capecitabine and Lapatinib in Rat Plasma.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmab094
Abstract: A chemometrics-oriented green ultra-performance liquid chromatography-mass spectrometry/mass spectrometry method was developed and validated for the first-time simultaneous estimation of capecitabine (CAP) and lapatinib (LPB) along with imatinib (as internal standard (IS)) in rat plasma. Analytes… read more here.
Keywords: rat plasma; validation; simultaneous estimation; method ... See more keywords
Overcoming Quantum Metrology Singularity through Sequential Measurements.
Sign Up to like & getrecommendations! Published in 2025 at "Physical review letters"
DOI: 10.1103/gsyv-jllq
Abstract: The simultaneous estimation of multiple unknown parameters is the most general scenario in quantum sensing. Quantum multiparameter estimation theory provides fundamental bounds on the achievable precision of simultaneous estimation. However, these bounds can become singular… read more here.
Keywords: sequential measurements; metrology; measurement; simultaneous estimation ... See more keywords
Simultaneous Estimation of Neutron Flux and Reactivity in Nuclear Reactors
Sign Up to like & getrecommendations! Published in 2020 at "IEEE Transactions on Nuclear Science"
DOI: 10.1109/tns.2020.3005115
Abstract: In this article, we propose a methodology based on cubature Kalman filtering (CKF) for simultaneous estimation of two important variables of nuclear reactors, viz. the neutron flux and the total core reactivity, from signals of… read more here.
Keywords: simultaneous estimation; reactivity; neutron flux; estimation ... See more keywords
Non-invasive kinetic modelling of PET tracers with radiometabolites using a constrained simultaneous estimation method: evaluation with 11C-SB201745
Sign Up to like & getrecommendations! Published in 2018 at "EJNMMI Research"
DOI: 10.1186/s13550-018-0412-6
Abstract: BackgroundKinetic analysis of dynamic PET data requires an accurate knowledge of available PET tracer concentration within blood plasma over time, known as the arterial input function (AIF). The gold standard method used to measure the… read more here.
Keywords: image derived; simultaneous estimation; method; estimation method ... See more keywords
Simultaneous estimation of the temporal and spatial extent of animal migration using step lengths and turning angles
Sign Up to like & getrecommendations! Published in 2024 at "Movement Ecology"
DOI: 10.1186/s40462-023-00444-8
Abstract: Background Animals of many different species, trophic levels, and life history strategies migrate, and the improvement of animal tracking technology allows ecologists to collect increasing amounts of detailed data on these movements. Understanding when animals… read more here.
Keywords: ferruginous hawks; migration; model; movement ... See more keywords